An aldol approach to a building block corresponding to the C21-C26-part of FK506

被引：0

作者：

Namyslo, JC ^{[1
]}

Schäfer, R ^{[1
]}

Maier, ME ^{[1
]}

机构：

[1] Univ Halle Wittenberg, Fachbereich Chem, Inst Organ Chem, D-4010 Halle, Saale, Germany

来源：

JOURNAL FUR PRAKTISCHE CHEMIE-CHEMIKER-ZEITUNG | 1999年 / 341卷 / 06期

关键词：

aldol reactions; chiral auxiliaries; chiron; tartrate; FK506;

D O I：

暂无

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Starting, from D-tartrate 2, the chiral aldehyde 10 was prepared in 8 steps. Key steps include the reductive opening of the p-methoxybenzyl acetal 4 and the elongation of the aldehyde 7 via Wittig and hydroboration reaction providing the alcohol 9. Subsequent Evans aldol reaction provided compound 12 which corresponds to the C21-C26 part of the immunosuppressive FK506.

引用

页码：557 / 561

页数：5

共 22 条

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