Interleukin-6 promoter polymorphism and late-onset Alzheimer's disease in the Finnish population

被引：23

作者：

Koivisto, AM

Helisalmi, S

Pihlajamäki, J

Moilanen, L

Kuusisto, J

Laakso, M

Hiltunen, M

Keijo, V

Hänninen, T

Helkala, EL

Kervinen, K

Kesäniemi, YA

Soininen, H

机构：

[1] Kuopio Univ Hosp, Dept Neurol, SF-70210 Kuopio, Finland

[2] Univ Kuopio, Clin Res Ctr Mediteknia, Dept Neurol, Brain Res Unit, FIN-70211 Kuopio, Finland

[3] Kuopio Univ Hosp, Dept Med, Kuopio, Finland

来源：

JOURNAL OF NEUROGENETICS | 2005年 / 19卷 / 3-4期

关键词：

Alzheimer's disease; dementia; interleukin-6; polymorphism; apolipoprotein E; geographical distribution;

D O I：

10.1080/01677060600569721

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recently, the involvement of the inflammatory response in Alzheimer's disease (AD) has received considerable attention. The gene encoding for interleukin-6 (IL-6) is interesting since IL-6 has been reported not only to be involved in immune functions but also in AD. We investigated whether the IL-6-174 G/C polymorphism is associated with late onset AD (LOAD) in the Finnish subjects. The G allele was over-represented in ApoE4-LOAD patients but remained unimportant in all and in the ApoE E4 carriers. Interestingly, the G allele frequency was lower in our population in both AD patients and in controls compared to Southern European populations.

引用

收藏

页码：155 / 161

页数：7

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