Leptin in Joint and Bone Diseases: New Insights

被引：25

作者：

Scotece, M. ^{[1
]}

Conde, J. ^{[1
]}

Lopez, V. ^{[1
]}

Lago, F. ^{[2
]}

Pino, J. ^{[3
]}

Gomez-Reino, J. J. ^{[1
]}

Gualillo, O. ^{[1
]}

机构：

[1] Santiago Univ Clin Hosp, Inst Med Res IDIS, NEIRID LAB Neuroendocrine Interact Rheumatol & In, SERGAS,Res Lab 9, Santiago De Compostela 15706, Spain

[2] Santiago Univ Clin Hosp, Inst Med Res IDIS, Res Lab Mol & Cellular Cardiol 7, SERGAS, Santiago De Compostela 15706, Spain

[3] Santiago Univ Clin Hosp, Div Orthopaed Surg, SERGAS, Santiago De Compostela 15706, Spain

来源：

CURRENT MEDICINAL CHEMISTRY | 2013年 / 20卷 / 27期

关键词：

Cartilage; chondrocyte; bone; inflammation; leptin; rheumatic diseases; synovium; INFRAPATELLAR FAT PAD; SYMPATHETIC-NERVOUS-SYSTEM; DIET-INDUCED OBESITY; BODY-MASS INDEX; RHEUMATOID-ARTHRITIS; ADIPOSE-TISSUE; WEIGHT-LOSS; KNEE OSTEOARTHRITIS; SYNOVIAL-FLUID; CHONDROCYTE DIFFERENTIATION;

D O I：

10.2174/0929867311320270006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Leptin is an adipokine with pleiotropic actions that regulates food intake, energy metabolism, inflammation and immunity, and also participates in the complex mechanism that regulates skeleton biology, both at bone and cartilage level. Leptin is increased in obesity and contributes to the "low-grade inflammatory state" of obese subjects causing a cluster of metabolic aberrations that affects joints and bone. In this review, we report the most recent research advances about the role of leptin in bone and cartilage function and its implication in inflammatory and degenerative joint diseases, such as osteoarthritis, rheumatoid arthritis and osteoporosis.

引用

页码：3416 / 3425

页数：10

共 92 条

[61] Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1 [J].