Mineralization of Calcium Phosphate Crystals in Starch Template Inducing a Brushite Kidney Stone Biomimetic Composite

被引：45

作者：

Gashti, Mazeyar Parvinzadeh ^{[1
,2
]}

Stir, Manuela ^{[1
]}

Bourquin, Marc ^{[1
]}

Hulliger, Juerg ^{[1
]}

机构：

[1] Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland

[2] Islamic Azad Univ, Dept Text, Shahre Rey Branch, Tehran, Iran

来源：

CRYSTAL GROWTH & DESIGN | 2013年 / 13卷 / 05期

关键词：

DICALCIUM PHOSPHATE; OCTACALCIUM PHOSPHATE; DIHYDRATE CRYSTALS; HYDROXYAPATITE; GELATION; GROWTH; TRANSFORMATION; GEL; CRYSTALLIZATION; GELATINIZATION;

D O I：

10.1021/cg4002434

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Dicalcium phosphate dihydrate (brushite) and octacalcium phosphate (OCP) crystals are precursors of hydroxyapatite (HAp) for tooth enamel, dentine, and bones formation in living organisms. Here, we introduce a new method for biomimicking brushite and OCP in starch using single and double diffusion techniques. Brushite and OCP crystals were grown by precipitation in starch after gelation. The obtained materials were analyzed by infrared spectroscopy (IR), scanning electron microscopy (SEM), X-ray, diffraction (XRD), and confocal laser scanning microscopy (CLSM). IR spectra demonstrate starch inclusion by peak shifts in the 2900-3500 cm(-1) region. SEM showed two different morphologies: plate-shaped and needle-like crystals. Calcium phosphate/starch aggregates bear strong resemblance to prismatic brushite kidney stones. This may open up a clue to understand the mechanism of kidney stone formation.

引用

页码：2166 / 2173

页数：8

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