Novel 5-(3-(Substituted)-4,5-dihydroisoxazol-5-yl)-2-methoxyphenyl Derivatives: Synthesis and Anticancer Activity

被引：5

作者：

Liu, Xin-Hua ^{[1
]}

Song, Bao-An ^{[3
]}

Bhadury, Pinaki S. ^{[3
]}

Zhu, Hai-Liang ^{[1
,2
]}

Cui, Ping ^{[1
]}

Hou, Ke-Ke ^{[3
]}

Xu, Hong-Li ^{[1
]}

机构：

[1] Anhui Univ Technol, Anhui Educ Dept, Key Lab, Maanshan 243002, Peoples R China

[2] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China

[3] Guizhou Univ, Minist Educ, Key Lab Green Pesticide & Agr Bioengn, Guiyang 55002, Peoples R China

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 2008年 / 61卷 / 11期

基金：

安徽省自然科学基金;

关键词：

D O I：

10.1071/CH07395

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Thirty novel 5-(3-(substituted phenyl)-4,5-dihydroisoxazol-5-yl)-2-methoxyphenyl derivatives were synthesized and evaluated for their antitumour activity. The bioassays showed that the 2-fluorobenzoyl derivative 6ai, the 4-trifluoromethylbenzoyl derivative 6ah, and the 3-trifluoromethyl isoxazole derivatives (6ch and 6ci) were highly effective against PC-3 cells. The IC50 values of 6ah and 6ai against PC-3 cells were 1.5 and 1.8 mu gmL(-1), respectively.

引用

页码：864 / 869

页数：6

共 23 条

[1] BUECHI G, 1972, Journal of the American Chemical Society, V94, P9128, DOI 10.1021/ja00781a023
[2] Synthesis and cytotoxic evaluation of substituted urea derivatives as inhibitors of human-leukemia K562 cells
Cao, Ping
Huang, Xian-Feng
Ding, Hui
Ge, Hui-Ming
Li, Huan-Qiu
Ruan, Ban-Feng
Zhu, Hai-Liang
[J]. CHEMISTRY & BIODIVERSITY, 2007, 4 (05) : 881 - 886
[3] Fluorine chemistry at the millennium
Dolbier, WR
[J]. JOURNAL OF FLUORINE CHEMISTRY, 2005, 126 (02) : 157 - 163
[4] FINKELSTEIN BL, 2002, J MED CHEM, V45, P599
[5] Fluorine in medicinal chemistry: A review of anti-cancer agents
Isanbor, C
O'Hagan, D
[J]. JOURNAL OF FLUORINE CHEMISTRY, 2006, 127 (03) : 303 - 319
[6] Synthesis, structure, and bioactivity of N′-substituted benzylidene-3,4,5-trimethoxybenzohydrazide and 3-acetyl-2-substituted phenyl-5-(3,4,5-trimethoxyphenyl)-2,3-dihydro-1,3,4-oxadiazole derivatives
Jin, Linhong
Chen, Jiang
Song, Baoan
Chen, Zhuo
Yang, Song
Li, Qianzhu
Hu, Deyu
Xu, Ruiqing
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (19) : 5036 - 5040
[7] Total synthesis of dimethyl sulfomycinamate
Kelly, TR
Lang, FR
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (14) : 4623 - 4633
[8] Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors:: Synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N′-{4-[4-quinolyloxy)phenyl}ureas
Kubo, K
Shimizu, T
Ohyama, S
Murooka, H
Iwai, A
Nakamura, K
Hasegawa, K
Kobayashi, Y
Takahashi, N
Takahashi, K
Kato, S
Izawa, T
Isoe, T
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (05) : 1359 - 1366
[9] Synthetic studies of the formation of oxazoles and isoxazoles from N-acetoacetyl derivatives:: Scope and limitations
Lautens, M
Roy, A
[J]. ORGANIC LETTERS, 2000, 2 (04) : 555 - 557
[10] LI L, 2004, J MED CHEM, V47, P1126

← 1 2 3 →