Anatomical Segregation of Visual Selection Mechanisms in Human Parietal Cortex

被引:44
作者
Capotosto, Paolo [1 ,2 ]
Tosoni, Annalisa [1 ,2 ]
Spadone, Sara [1 ,2 ]
Sestieri, Carlo [1 ,2 ]
Perrucci, Mauro Gianni [1 ,2 ]
Romani, Gian Luca [1 ,2 ]
Della Penna, Stefania [1 ,2 ]
Corbetta, Maurizio [1 ,2 ,3 ]
机构
[1] Gabriele DAnnunzio Univ, Dept Neurosci & Imaging, I-66110 Chieti, Italy
[2] Gabriele DAnnunzio Univ, Inst Adv Biomed Technol, I-66110 Chieti, Italy
[3] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA
关键词
SPATIAL ATTENTION; FRONTOPARIETAL CORTEX; MAGNETIC STIMULATION; SHIFTS; BRAIN; ACTIVATION; NETWORKS; DORSAL;
D O I
10.1523/JNEUROSCI.4983-12.2013
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Visual selection requires mechanisms for representing object salience and for shifting the focus of processing to novel objects. It is not clear from computational or neural models whether these operations are performed within the same or different brain regions. Here, we use repetitive transcranial magnetic stimulation to briefly interfere with neural activity in individually localized regions of human posterior parietal cortex (PPC) that are putatively involved in attending to contralateral locations or shifting attention between locations. Stimulation over right ventral intraparietal sulcus impaired target discrimination at contralateral locations, whereas stimulation over right medial superior parietal lobule impaired target discrimination after a shift of attention regardless of its location. This double dissociation is consistent with neuroimaging studies and indicates that mechanisms of visual selection are partly anatomically segregated in human PPC.
引用
收藏
页码:6225 / 6229
页数:5
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