Replicon particle vaccine protects swine against influenza

被引：26

作者：

Bosworth, B. ^{[1
]}

Erdman, M. M. ^{[2
]}

Stine, D. L. ^{[3
]}

Harris, I. ^{[1
]}

Irwin, C. ^{[2
]}

Jens, M. ^{[4
]}

Loynachan, A. ^{[2
]}

Kamrud, K. ^{[5
]}

Harris, D. L. ^{[1
,2
,6
]}

机构：

[1] Iowa State Univ, Coll Agr, Dept Anim Sci, Ames, IA 50010 USA

[2] Iowa State Univ, Coll Vet Med, Dept Vet Diagnost & Prod Anim Med, Ames, IA 50010 USA

[3] Newport Labs, Worthington, MN 56187 USA

[4] AMVC Management Serv, Audubon, IA 50025 USA

[5] Alphavax Inc, Res Triangle Pk, NC 27709 USA

[6] Harrisvaccines Inc, Ames, IA 50010 USA

来源：

COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES | 2010年 / 33卷 / 06期

关键词：

Swine influenza virus (SIV); Hemagglutinin (HA); Replicon particle (RP) vaccine; Swine; Pigs; Maternal antibody; VIRUSES; CHALLENGE; PIGS;

D O I：

10.1016/j.cimid.2010.05.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An alphavirus derived replicon particle (RP) vaccine expressing the cluster IV H3N2 swine influenza virus (SIV) hemagglutinin (HA) gene induced protective immunity against homologous influenza virus challenge. However, pigs with maternal antibody had no protective immunity against challenge after vaccination with RP vaccines expressing HA gene alone or in combination with nucleoprotein gene. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：E99 / E103

页数：5

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