Oral lichen sclerosus: a systematic review of reported cases and two new cases

被引:15
作者
Kakko, Tuomas [1 ]
Salo, Tuula [2 ,3 ,4 ,5 ]
Siponen, Maria K. [2 ,3 ,6 ,7 ]
机构
[1] Univ Oulu, Inst Dent, Fac Med, Oulu, Finland
[2] Univ Oulu, Fac Med, Canc & Translat Med Res Unit, Oulu, Finland
[3] Oulu Univ Hosp, Oulu, Finland
[4] Univ Helsinki, Dept Oral & Maxillofacial Dis, Oulu, Finland
[5] Oulu Univ Hosp, Med Res Ctr, Oulu, Finland
[6] Kuopio Univ Hosp, Dept Oral & Maxillofacial Dis, Kuopio, Finland
[7] Univ Eastern Finland, Fac Hlth Sci, Inst Dent, Kuopio, Finland
关键词
EXTRACELLULAR-MATRIX PROTEIN-1; SQUAMOUS-CELL CARCINOMA; RARE CASE-REPORT; ET-ATROPHICUS; AUTOIMMUNE-DISEASE; MUCOSA; ASSOCIATION; AUTOANTIBODIES; SUSCEPTIBILITY; ANTIGENS;
D O I
10.1111/ijd.13870
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Lichen sclerosus (LS) is a chronic inflammatory mucocutaneous disease with uncertain etiology. It occurs as white plaque-like lesions mostly in the anogenital skin. Oral mucosal involvement is extremely rare. This study aims to summarize the features of published oral lichen sclerosus (OLS) and two new cases. A systematic search of the English literature from 1955 to 2016 was performed in MEDLINE, Scopus, and Web of Science, and cross-references were searched manually. Search phrases included lichen sclerosus, mouth, oral, lip, palate, floor of mouth, tongue, gingiva, buccal mucosa, and mouth diseases. Cases with clinical and histopathological confirmation of diagnosis of OLS were included. A total of 41 (39 published and 2 new) histologically confirmed OLS cases were available. The median age of OLS patients was 31 years, and 66% of the patients were female. Most of the OLS lesions were asymptomatic. They were located in the labial mucosa (n = 20), lip (n = 15), buccal mucosa (n = 14), gingiva (n = 12), tongue (n = 12), and palate (n = 7). OLS is rare and typically presents as asymptomatic, white, plaque-like lesions. Malignant transformation of preexisting OLS has not been reported.
引用
收藏
页码:521 / 528
页数:8
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