ONE-POT SYNTHESIS OF 9-SPIROFLUORENES VIA TANDEM COPPER-CATALYZED ARYLATIVE CYCLIZATION AND SPIROCYCLIZATION OF BIARYL-SUBSTITUTED ALKYNYL ALCOHOLS

被引：0

作者：

Yanada, Reiko ^{[1
]}

Okamoto, Noriko ^{[1
]}

Sueda, Takuya ^{[1
]}

机构：

[1] Hiroshima Int Univ, Fac Pharmaceut Sci, 5-1-1 Hirokoshingai, Kure, Hiroshima 7370112, Japan

来源：

HETEROCYCLES | 2020年 / 101卷 / 02期

基金：

日本学术振兴会;

关键词：

DIARYLIODONIUM SALTS; ELECTROPHILIC CARBOFUNCTIONALIZATION; INTRAMOLECULAR DEAROMATIZATION; STEREOSELECTIVE-SYNTHESIS; NATURAL-PRODUCTS; SPIRO; CHEMISTRY; CARBOARYLATION; REARRANGEMENT; CONSTRUCTION;

D O I：

10.3987/COM-19-S(F)22

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A tandem copper-catalyzed arylative cyclization and spirocyclization strategy to access spiro cyclic compounds is described. This method enables the one-pot construction of 9-spirofluorenes from readily available alkynyl alcohols with biaryl-substituents via the copper-catalyzed arylative ring-closing reaction and the Friedel Crafts reaction.

引用

页码：407 / 416

页数：10

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