Response assessment in Waldenstrom macroglobulinaemia: update from the VIth International Workshop

被引：225

作者：

Owen, Roger G. ^{[1
]}

Kyle, Robert A. ^{[2
]}

Stone, Marvin J. ^{[3
]}

Rawstron, Andy C.

Leblond, Veronique ^{[4
]}

Merlini, Giampaolo ^{[5
,6
]}

Garcia-Sanz, Ramon ^{[7
]}

Ocio, Enrique M. ^{[7
]}

Morra, Enrica ^{[8
]}

Morel, Pierre ^{[9
]}

Anderson, Kenneth C. ^{[10
]}

Patterson, Christopher J. ^{[10
]}

Munshi, Nikhil C. ^{[10
]}

Tedeschi, Alessandra ^{[8
]}

Joshua, Douglas E. ^{[11
]}

Kastritis, Efstathios ^{[12
]}

Terpos, Evangelos ^{[12
]}

Ghobrial, Irene M. ^{[10
]}

Leleu, Xavier ^{[13
]}

Gertz, Morie A. ^{[2
]}

Ansell, Stephen M. ^{[2
]}

Morice, William G. ^{[2
]}

Kimby, Eva ^{[14
,15
]}

Treon, Steven P. ^{[10
]}

机构：

[1] St James Univ Hosp, HMDS Lab, Leeds LS9 7TF, W Yorkshire, England

[2] Mayo Clin & Mayo Fdn, Mayo Med Sch, Rochester, MN 55905 USA

[3] Baylor Sammons Canc Ctr, Dallas, TX USA

[4] Hop La Pitie Salpetriere, Paris, France

[5] IRCCS Policlin San Matteo, Pavia, Italy

[6] Univ Pavia, I-27100 Pavia, Italy

[7] Hosp Univ Salamanca, Salamanca, Spain

[8] Osped Niguarda Ca Granda, Milan, Italy

[9] Hosp Schaffner, Lens, France

[10] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA

[11] Royal Prince Alfred Hosp, Sydney, NSW, Australia

[12] Univ Athens, Sch Med, GR-11527 Athens, Greece

[13] Ctr Hosp Reg & Univ Lille, Hop Huriez, F-59037 Lille, France

[14] Karolinska Inst, Stockholm, Sweden

[15] Karolinska Univ Hosp, Stockholm, Sweden

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2013年 / 160卷 / 02期

关键词：

Waldenstrom macroglobulinaemia; trials; residual disease; FREE LIGHT-CHAIN; CONSENSUS PANEL RECOMMENDATIONS; CHRONIC LYMPHOCYTIC-LEUKEMIA; NATIONAL-CANCER-INSTITUTE; MULTIPLE-MYELOMA; RESIDUAL DISEASE; PROGRESSION-FREE; CLINICAL-TRIAL; IMMUNOGLOBULIN; BORTEZOMIB;

D O I：

10.1111/bjh.12102

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This report represents a further update of the consensus panel criteria for the assessment of clinical response in patients with Waldenstrom macroglobulinaemia (WM). These criteria have been updated in light of further data demonstrating an improvement in categorical responses with new drug regimens as well as acknowledgement of the fact that such responses are predictive of overall outcome. A number of key changes are proposed but challenges do however remain and these include the variability in kinetics of immunoglobulin M (IgM) reduction with different treatment modalities and the apparent discrepancy between IgM and bone marrow/tissue response noted with some regimens. Planned sequential bone marrow assessments are encouraged in clinical trials.

引用

页码：171 / 176

页数：6

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