Omega-3 Phospholipids from Krill Oil Enhance Intestinal Fatty Acid Oxidation More Effectively than Omega-3 Triacylglycerols in High-Fat Diet-Fed Obese Mice

被引:25
作者
Kroupova, Petra [1 ]
van Schothorst, Evert M. [2 ]
Keijer, Jaap [2 ]
Bunschoten, Annelies [2 ]
Vodicka, Martin [3 ]
Irodenko, Ilaria [1 ]
Oseeva, Marina [1 ]
Zacek, Petr [4 ]
Kopecky, Jan [1 ]
Rossmeisl, Martin [1 ]
Horakova, Olga [1 ]
机构
[1] Czech Acad Sci, Lab Adipose Tissue Biol, Inst Physiol, Videnska 1083, Prague 14220, Czech Republic
[2] Wageningen Univ, Human & Anim Physiol, NL-6708 WD Wageningen, Netherlands
[3] Czech Acad Sci, Lab Epithelial Physiol, Inst Physiol, Prague 14220, Czech Republic
[4] Charles Univ Prague, Fac Sci, Div BIOCEV, Prote Core Facil, Vestec 25250, Czech Republic
关键词
krill oil; Omega-3; phospholipids; high-fat diet; index; small intestine; FISH-OIL; LIPID-METABOLISM; BETA-OXIDATION; EPA; DHA; MITOCHONDRIAL; ABSORPTION; OVERWEIGHT; EXPRESSION; MARKER;
D O I
10.3390/nu12072037
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Antisteatotic effects of omega-3 fatty acids (Omega-3) in obese rodents seem to vary depending on the lipid form of their administration. Whether these effects could reflect changes in intestinal metabolism is unknown. Here, we compare Omega-3-containing phospholipids (krill oil; omega 3PL-H) and triacylglycerols (omega 3TG) in terms of their effects on morphology, gene expression and fatty acid (FA) oxidation in the small intestine. Male C57BL/6N mice were fed for 8 weeks with a high-fat diet (HFD) alone or supplemented with 30 mg/g diet of omega 3TG or omega 3PL-H. Omega-3 index, reflecting the bioavailability of Omega-3, reached 12.5% and 7.5% in the omega 3PL-H and omega 3TG groups, respectively. Compared to HFD mice, omega 3PL-H but not omega 3TG animals had lower body weight gain (-40%), mesenteric adipose tissue (-43%), and hepatic lipid content (-64%). The highest number and expression level of regulated intestinal genes was observed in omega 3PL-H mice. The expression of FA omega-oxidation genes was enhanced in both Omega-3-supplemented groups, but gene expression within the FA beta-oxidation pathway and functional palmitate oxidation in the proximal ileum was significantly increased only in omega 3PL-H mice. In conclusion, enhanced intestinal FA oxidation could contribute to the strong antisteatotic effects of Omega-3 when administered as phospholipids to dietary obese mice.
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页码:1 / 20
页数:20
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