Neurologic Consequences of Neonatal Necrotizing Enterocolitis

被引：21

作者：

Berken, Jonathan A. A. ^{[1
,3
]}

Chang, Jill ^{[1
,2
]}

机构：

[1] Ann & Robert H Lurie Childrens Hosp Chicago, Dept Pediat, Chicago, IL 60611 USA

[2] Ann & Robert H Lurie Childrens Hosp Chicago, Div Neonatal Perinatal Med, Chicago, IL 60611 USA

[3] Ann & Robert H Lurie Childrens Hosp Chicago, Dept Pediat, Chicago, IL 61611 USA

来源：

DEVELOPMENTAL NEUROSCIENCE | 2022年 / 44卷 / 4-5期

关键词：

Brain injury; Cytokine; Developing brain; Inflammation; Microglia; Myelination; Neonatal brain injury; Neuroinflammation; Oligodendrocyte; BIRTH-WEIGHT INFANTS; LATE OLIGODENDROCYTE PROGENITORS; INTESTINAL PERFORATION; PRETERM INFANTS; PERITONEAL DRAINAGE; HUMAN-MILK; NEURODEVELOPMENTAL OUTCOMES; SYSTEMIC INFLAMMATION; SURGICAL-MANAGEMENT; POSTNATAL SEPSIS;

D O I：

10.1159/000525378

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease of the premature infant with high mortality and morbidity. Children who survive NEC have been shown to demonstrate neurodevelopmental delay, with significantly worse outcomes than from prematurity alone. The pathways leading to NEC-associated neurological impairments remain unclear, limiting the development of preventative and protective strategies. This review aims to summarize the existing clinical and experimental studies related to NEC-associated brain injury. We describe the current epidemiology of NEC, reported long-term neurodevelopmental outcomes among survivors, and proposed pathogenesis of brain injury in NEC. Highlighted are the potential connections between hypoxia-ischemia, nutrition, infection, gut inflammation, and the developing brain in NEC.

引用

页码：295 / 308

页数：14

共 120 条

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