Phosphonite mediated 1,3-dipolar cycloaddition: a route to polycyclic 2-pyrrolines from imines, acid chlorides and alkenes

被引：13
作者：
Morin, Marie S. T. [1 ]
Aly, Sara [1 ]
Arndtsen, Bruce A. [1 ]
机构：
[1] McGill Univ, Dept Chem, Montreal, PQ H3A 0B8, Canada
来源：
CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 09期
关键词：
FORMAL 3+2 CYCLOADDITION; AZOMETHINE YLIDES; PYRROLE SYNTHESIS; CYCLO-ADDITIONS; AMINO-ACIDS; DERIVATIVES; AZIRIDINES; 2,3-DIHYDROPYRROLES; DIHYDROPYRROLES; ANALOGS;
D O I：
10.1039/c2cc38274a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
2-Pyrrolines can be generated by the PhP(2-catechyl) mediated coupling of alkene-tethered imines and acid chlorides. This reaction proceeds via phosphorus-containing 1,3-dipoles, which undergo cycloaddition with alkenes with high stereo- and regioselectivity. The modularity of this reaction can be used to assemble a range of polysubstituted pyrrolines in one pot transformations.
引用
收藏
页码：883 / 885
页数：3
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