Understanding the RECORDS 3 Trial and its impact on anticiagulation practice in resource poor countries

被引：1

作者：

Nwagha, T. U. ^{[1
]}

Omunakwe, H. E. ^{[2
]}

机构：

[1] Univ Nigeria, Teaching Hosp, Bleeding & Thrombosis Unit, Dept Haematol & Immunol, Ituku Ozalla, Enugu, Nigeria

[2] Braithwaite Mem Specialist Hosp, Hematol Unit, Dept Pathol, Port Harcourt, Rivers State, Nigeria

来源：

NIGERIAN JOURNAL OF CLINICAL PRACTICE | 2016年 / 19卷 / 06期

关键词：

Anticoagulation practice; new anticoagulation therapy; Regulation of Coagulation in Orthopedic surgery to prevent Deep venous thrombosis and pulmonary embolism 3 trial; rivaroxaban; DEEP-VEIN THROMBOSIS; FACTOR-XA INHIBITOR; VENOUS THROMBOEMBOLISM; RIVAROXABAN BAY-59-7939; TOTAL HIP; PREVENTION; THROMBOPROPHYLAXIS; PHARMACOKINETICS; WEIGHT;

D O I：

10.4103/1119-3077.180059

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Venous thromboembolism is a significant cause of mortality and morbidity in patients following major orthopaedic surgeries. The RECORDS 3 trial revolutionised anticoagulation practice especially in patients with total knee arthroplasty and challenging the strong hold of warfarin and heparin in anticoagulation practice. With all these novel agents shifting the paradigm in anticoagulation management, Cost, in accessibility and lack of awareness of the availability of the agents amongst clinicians and surgeons alike are some factors militating against the use of these agents in patients in resource poor countries.

引用

页码：695 / 699

页数：5

共 26 条

[21]

Rübenacker S, 2013, CHIRURG, V84, P235, DOI 10.1007/s00104-012-2443-2

[22]

Russell Robert D, 2013, Thrombosis, V2013, P762310, DOI 10.1155/2013/762310

[23] The effect of food on the absorption and pharmacokinetics of rivaroxaban [J].

Stampfuss, Jan ;

Kubitza, Dagmar ;

Becka, Michael ;

Mueck, Wolfgang .

INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2013, 51 (07) :549-561

[24]

Stephens Joe, 2006, WASH POST

[25] Metabolism and Excretion of Rivaroxaban, an Oral, Direct Factor Xa Inhibitor, in Rats, Dogs, and Humans [J].

Weinz, C. ;

Schwarz, T. ;

Kubitza, D. ;

Mueck, W. ;

Lang, D. .

DRUG METABOLISM AND DISPOSITION, 2009, 37 (05) :1056-1064

[26] Has the incidence of deep vein thrombosis in patients undergoing total hip/knee arthroplasty changed over time? A systematic review of randomized controlled trials [J].

Xing, Katharine He ;

Morrison, Gareth ;

Lim, Wendy ;

Douketis, James ;

Odueyungbo, Adefowope ;

Crowther, Mark .

THROMBOSIS RESEARCH, 2008, 123 (01) :24-34

← 1 2 3 →