Reactions of 3-formylchromone with active methylene and methyl compounds and some subsequent reactions of the resulting condensation products.

被引：48

作者：

Gasparová, R

Lácová, M

机构：

[1] Univ St Cyril & Methudius, Dept Chem, Fac Nat Sci, SK-91701 Trnava, Slovakia

[2] Comenius Univ, Fac Nat Sci, Dept Organ Chem, SK-84215 Bratislava, Slovakia

来源：

MOLECULES | 2005年 / 10卷 / 08期

关键词：

3-formylchromone; Knoevenagel condensation; active methylene compound; active methyl compound; microwave irradiation; biological activity;

D O I：

10.3390/10080937

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review presents a survey of the condensations of 3-formylchromone with various active methylene and methyl compounds, e.g. malonic or barbituric acid derivatives, five-membered heterocycles, etc. The utilisation of the condensation products for the synthesis of different heterocyclic systems, which is based on the ability of the gamma-pyrone ring to be opened by the nucleophilic attack is also reviewed. Finally, the applications of microwave irradiation as an unconventional method of reaction activation in the synthesis of condensation products is described and the biological activity of some chromone derivatives is noted.

引用

页码：937 / 960

页数：24