DNA-binding and cleavage activity of polypyridyl ruthenium(II) complexes

被引：19

作者：

Patel, Mohan N. ^{[1
]}

Gandhi, Deepen S. ^{[1
]}

Parmar, Pradhuman A. ^{[1
]}

Joshi, Hardik N. ^{[1
]}

机构：

[1] Sardar Patel Univ, Dept Chem, Vallabh Vidyanagar 388120, Gujarat, India

来源：

JOURNAL OF COORDINATION CHEMISTRY | 2012年 / 65卷 / 11期

关键词：

Terpyridine; Ruthenium(II) complexes; pUC19; DNA-binding and cleavage; CRYSTAL-STRUCTURE; TERPYRIDINE COMPLEXES; COBALT COMPLEXES; LIGANDS; PHOTOCLEAVAGE; DERIVATIVES; POLYMER; DFT; PNA;

D O I：

10.1080/00958972.2012.685728

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Polypyridyl ruthenium(II) complexes [Ru-II(3-bptpy)(dmphen)Cl]ClO4 (1), [Ru-II(3-cptpy) (dmphen) Cl] ClO4 (2), [Ru-II(2-tptpy)(dmphen) Cl]ClO4 (3), and [Ru-II(9-atpy)(dmphen)Cl]ClO4 (4) {where 3-bptpy 4'-(3-bromophenyl)-2,2':6',2 ''-terpyridine, 3-cptpy 4'-(3-chlorophenyl)-2,2':6',2 ''-terpyridine, 2-tptpy 4'-(2-thiophenyl)-2,2':6',2 ''-terpyridine, 9-atpy 4'-(9-anthryl)-2,2':6',2 ''-terpyridine, dmphen 2,9-dimethyl-1,10-phenanthroline} have been synthesized and characterized. The DNA-binding properties of the complexes with Herring Sperm DNA have been investigated by absorption titration and viscosity measurements. The ability of complexes to break the pUC19 DNA has been checked by gel electrophoresis. The experimental results suggest that all the complexes bind DNA via partial intercalation. The results also show that the order of DNA-binding affinities of the complexes is 4 < 3 < 2 < 1, confirming that planarity of the ligand in a complex is very important for DNA-binding.

引用

页码：1926 / 1936

页数：11

共 46 条

[1] Synthesis and DNA-binding studies of two ruthenium(II) complexes of an intercalating ligand [J].

Arockiasamy, D. Lawrence ;

Radhika, S. ;

Parthasarathi, R. ;

Nair, Balachandran Unni .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (05) :2044-2051

[2] From ruthenium(II) to iridium(III): 15 years of triads based on bis-terpyridine complexes [J].

Baranoff, E ;

Collin, JP ;

Flamigni, L ;

Sauvage, JP .

CHEMICAL SOCIETY REVIEWS, 2004, 33 (03) :147-155

[3] A high-frequency EPR study of frozen solutions of GdIII complexes:: Straightforward determination of the zero-field splitting parameters and simulation of the NMRD profiles [J].

Benmelouka, Meriem ;

Van Tol, Johan ;

Borel, Alain ;

Port, Marc ;

Helm, Lothar ;

Brunel, Louis Claude ;

Merbach, Andre E. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (24) :7807-7816

[4] Synthesis, Characterization, Photophysical, and Anion-Binding Studies of Luminescent Heteroleptic Bis-Tridentate Ruthenium(II) Complexes Based on 2,6-Bis(Benzimidazole-2-yl)Pyridine and 4'-Substituted 2,2′:6′,2" Terpyridine Derivatives [J].

Bhaumik, Chanchal ;

Das, Shyamal ;

Saha, Debasish ;

Dutta, Supriya ;

Baitalik, Sujoy .

INORGANIC CHEMISTRY, 2010, 49 (11) :5049-5062

[5] Stepwise synthesis of [Ru(trpy)(L)(X)]n+ (trpy=2,2′:6′,2"-terpyridine; L=2,2′-dipyridylamine; X = Cl-, H2O, NO2-, NO+, O2-).: Crystal structure, spectral, electron-transfer, and photophysical aspects [J].

Chanda, N ;

Mobin, SM ;

Puranik, VG ;

Datta, A ;

Niemeyer, M ;

Lahiri, GK .

INORGANIC CHEMISTRY, 2004, 43 (03) :1056-1064

[6] DNA binding studies of ruthenium(II) complexes containing asymmetric tridentate ligands [J].

Chao, H ;

Mei, WJ ;

Huang, QW ;

Ji, LN .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2002, 92 (3-4) :165-170

[7] Stannoxane capping derived from chiral tridentate NN donor ligand for nickel and copper macrocycles: Comparative binding studies of stannoxane moiety and its modulated copper complex with CTDNA [J].

Chauhan, Mala ;

Arjmand, Farukh .

JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2007, 692 (23) :5156-5164

[8] DNA binding and cleavage behaviors of copper(II) complexes with amidino-O-methylurea and N-methylphenyl-amidino-O-methylurea, and their antibacterial activities [J].

Chaveerach, Unchulee ;

Meenongwa, Atittaya ;

Trongpanich, Yanee ;

Soikum, Chaiyaporn ;

Chaveerach, Prapansak .

POLYHEDRON, 2010, 29 (02) :731-738

[9] Synthesis, characterization, structures and DNA-binding properties of complexes [Ru(bPY)2(L)]2+ (L = ptdb, ptda and ptdp) with asymmetric intercalative ligands [J].

Deng, H ;

Li, J ;

Zheng, KC ;

Yang, Y ;

Chao, H ;

Ji, LN .

INORGANICA CHIMICA ACTA, 2005, 358 (12) :3430-3440

[10] Hydrolytic cleavage of DNA by a ruthenium(II) polypyridyl complex [J].

Deshpande, Megha S. ;

Kumbhar, Anupa A. ;

Kumbhar, Avinash S. .

INORGANIC CHEMISTRY, 2007, 46 (14) :5450-5452

← 1 2 3 4 5 →