Searching for better animal models of BPD: a perspective

被引：45

作者：

Ambalavanan, Namasivayam ^{[1
]}

Morty, Rory E. ^{[2
]}

机构：

[1] Univ Alabama Birmingham, Dept Pediat, Div Neonatol, Birmingham, AL 35249 USA

[2] Max Planck Inst Heart & Lung Res, Dept Lung Dev & Remodelling, Bad Nauheim, Germany

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | 2016年 / 311卷 / 05期

关键词：

lung development; lung injury; animal models; infant; premature; diseases; bronchopulmonary dysplasia; BRONCHOPULMONARY DYSPLASIA; LUNG ALVEOLARIZATION; PRETERM; MOUSE; LAMBS; IDENTIFICATION; HYPEROXIA; STATEMENT; OUTCOMES;

D O I：

10.1152/ajplung.00355.2016

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

There have been many efforts to develop good animal models of bronchopulmonary dysplasia (BPD) to better understand the pathophysiology and mechanisms underlying development of BPD as well as to test potential strategies for its prevention and treatment. This Perspectives summarizes the features of common animal models of BPD and the strengths and limitations of such models. Potential optimal approaches to development of animal models are indicated, with the underlying concepts that require emphasis.

引用

页码：L924 / L927

页数：4

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