Intracellular Adaptation of Brucella abortus

被引：75

作者：

Larnontagne, Julie ^{[1
]}

Forest, Anik ^{[1
]}

Marazzo, Elena ^{[1
]}

Denis, Francois ^{[1
]}

Butler, Heather ^{[1
]}

Michaud, Jean-Francois ^{[1
]}

Boucher, Lyne ^{[1
]}

Pedro, Ida ^{[1
]}

Villeneuve, Annie ^{[1
]}

Sitnikov, Dmitri ^{[1
]}

Trudel, Karine ^{[1
]}

Nassif, Najib ^{[1
]}

Boudjelti, Djamila ^{[1
]}

Tomaki, Fadi ^{[1
]}

Chaves-Olarte, Esteban ^{[2
,3
]}

Guzman-Verri, Caterina ^{[2
]}

Brunet, Sylvain ^{[1
]}

Cote-Martin, Alexandra ^{[1
]}

Hunter, Joanna ^{[1
]}

Moreno, Edgardo ^{[2
]}

Paramithiotis, Eustache ^{[1
]}

机构：

[1] Capr Prote Inc, Montreal, PQ H4S 2C8, Canada

[2] Univ Nacl, Escuela Med Vet, Programa Invest Enfermedades Trop, Heredia, Costa Rica

[3] Univ Costa Rica, Fac Microbiol, Ctr Invest Enfermedades Trop, San Jose, Costa Rica

来源：

JOURNAL OF PROTEOME RESEARCH | 2009年 / 8卷 / 03期

关键词：

Brucella abortus; virulence; timecourse; proteomics; intracellular infection; OUTER-MEMBRANE PROTEINS; GENOME SEQUENCE; GENE-EXPRESSION; VIRULENCE; IDENTIFICATION; MELITENSIS; SYSTEM; MODULATION; ACTIVATION; INFECTION;

D O I：

10.1021/pr800978p

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Macrophages were infected with virulent Brucella abortus strain 2308 or attenuated strain 19. Intracellular bacteria were recovered at different times after infection and their proteomes compared. The virulent strain initially reduced most biosynthesis and altered its respiration; adaptations reversed later in infection. The attenuated strain was unable to match the magnitude of the virulent strain's adjustments. The results provide insight into mechanisms utilized by Brucella to establish intracellular infections.

引用

页码：1594 / 1609

页数：16

共 65 条

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