Detection of Pathologic Prion Protein in the Olfactory Bulb of Natural and Experimental Bovine Spongiform Encephalopathy Affected Cattle in Great Britain

被引：5

作者：

Lee, Y. H. ^{[2
]}

Simmons, M. M. ^{[1
]}

Hawkins, S. A. C. ^{[1
]}

Spencer, Y. I. ^{[1
]}

Webb, P. ^{[1
]}

Stack, M. J. ^{[1
]}

Wells, G. A. H. ^{[1
]}

机构：

[1] Vet Labs Agcy, Addlestone KT15 3NB, Surrey, England

[2] Natl Vet Res & Quarantine Serv, Anyang, South Korea

来源：

VETERINARY PATHOLOGY | 2009年 / 46卷 / 01期

关键词：

BSE; olfactory bulb; olfactory glomeruli; PrPSc; PrPC; INFECTION; DISEASE; SHEEP; BSE;

D O I：

10.1354/vp.46-1-59

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

To investigate the relative involvement of the olfactory region in classical bovine spongiform encephalopathy (BSE), immunohistochemical labeling of prion protein scrapie (PrPSc) was scored in the brainstem, frontal cerebral cortex, and olfactory bulb of cattle with natural and experimental clinical cases of BSE in Great Britain. The intensity Of immunolabeling was greatest in the brainstem, but PrPSc was also detected in the olfactory bulb and the cerebral cortex. A diffuse, non particulate labeling, possibly due to abundance of cellular PrP, was consistently observed in the olfactory glomeruli of the cases and negative controls. Involvement of the olfactory bulb in BSE and other naturally Occurring TSEs of animals raises Speculation as to an olfactory portal of infection or a route of excretion of the prion agent.

引用

收藏

页码：59 / 62

页数：4

相关论文

共 12 条

[1] Estimating the temporal relationship between PrPSc detection and incubation period in experimental bovine spongiform encephalopathy of cattle [J].

Arnold, M. E. ;

Ryan, J. B. M. ;

Konold, T. ;

Simmons, M. M. ;

Spencer, Y. I. ;

Wear, A. ;

Chaplin, M. ;

Stack, M. ;

Czub, S. ;

Mueller, R. ;

Webb, P. R. ;

Davis, A. ;

Spiropoulos, J. ;

Holdaway, J. ;

Hawkins, S. A. C. ;

Austin, A. R. ;

Wells, G. A. H. .

JOURNAL OF GENERAL VIROLOGY, 2007, 88 :3198-3208

[2] BSE immunohistochemical patterns in the brainstem: a comparison between UK and Italian cases [J].

Casalone, C ;

Caramelli, M ;

Crescio, MI ;

Spencer, YI ;

Simmons, MM .

ACTA NEUROPATHOLOGICA, 2006, 111 (05) :444-449

[3] Identification of a second bovine amyloidotic spongiform encephalopathy: Molecular similarities with sporadic Creutzfeldt-Jakob disease [J].

Casalone, C ;

Zanusso, G ;

Acutis, P ;

Ferrari, S ;

Capucci, L ;

Tagliavini, F ;

Monaco, S ;

Caramelli, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (09) :3065-3070

[4] Prion infection of oral and nasal mucosa [J].

DeJoia, C ;

Moreaux, B ;

O'Connell, K ;

Bessen, RA .

JOURNAL OF VIROLOGY, 2006, 80 (09) :4546-4556

[5] NATURAL INFECTION OF SUFFOLK SHEEP WITH SCRAPIE VIRUS [J].

HADLOW, WJ ;

KENNEDY, RC ;

RACE, RE .

JOURNAL OF INFECTIOUS DISEASES, 1982, 146 (05) :657-664

[6] Olfactory transmission of neurotropic viruses [J].

Mori, I ;

Nishiyama, Y ;

Yokochi, T ;

Kimura, Y .

JOURNAL OF NEUROVIROLOGY, 2005, 11 (02) :129-137

[7] Cerebrospinal fluid outflow resistance in sheep: impact of blocking cerebrospinal fluid transport through the cribriform plate [J].

Silver, I ;

Kim, C ;

Mollanji, R ;

Johnston, M .

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2002, 28 (01) :67-74

[8] Comparison of histological lesions and immunohistochemical staining of proteinase-resistant prion protein in a naturally occurring spongiform encephalopathy of free-ranging mule deer (Odocoileus hemionus) with those of chronic wasting disease of captive mule deer [J].

Spraker, TR ;

Zink, RR ;

Cummings, BA ;

Wild, MA ;

Miller, MW ;

O'Rourke, KI .

VETERINARY PATHOLOGY, 2002, 39 (01) :110-119

[9]

STACK MJ, 2004, METHODS TOOLS BIOSCI, P97

[10] First case of H-type bovine spongiform encephalopathy identified in Great Britain [J].

Terry, L. A. ;

Jenkins, R. ;

Thorne, L. ;

Everest, S. J. ;

Chaplin, M. J. ;

Davis, L. A. ;

Stack, M. J. .

VETERINARY RECORD, 2007, 160 (25) :873-875