NBS mediated nitriles synthesis through C=C double bond cleavage

被引：33

作者：

Zong, Xiaolin ^{[1
]}

Zheng, Qing-Zhong ^{[1
]}

Jiao, Ning ^{[1
,2
]}

机构：

[1] Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

[2] Peking Univ, Sch Chem Biol & Biotechnol, Lab Chem Genom, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 08期

基金：

美国国家科学基金会;

关键词：

C-H CYANATION; DIRECT TRANSFORMATION; HIGHLY EFFICIENT; PRIMARY AMIDES; ARYL; ALCOHOLS; ALDEHYDES; CATALYST; STEREOCHEMISTRY; HYDROGENATION;

D O I：

10.1039/c3ob42118j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An NBS mediated nitriles synthesis through C=C double bond cleavage has been developed. TMSN3 was employed as the nitrogen source for this Cu(OAc)(2) promoted nitrogenation reaction. This transformation has a relatively high regio-selectivity to form aromatic nitriles.

引用

页码：1198 / 1202

页数：5

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