"One pot" synthesis of tertiary amines: Ru(II) catalyzed direct reductive N-benzylation of imines with benzyl bromide derivatives

被引：5
作者：
Li, Bin [1 ]
Yu, Jinghao [1 ,2 ]
Li, Caihua [1 ]
Li, Yibiao [1 ]
Luo, Jianli [2 ]
Shao, Yan [1 ]
机构：
[1] Wuyi Univ, Sch Chem & Environm Engn, Jiangmen 529020, Guangdong, Peoples R China
[2] Guangdong Wamo New Mat Technol Co Ltd, Jiangmen 529020, Guangdong, Peoples R China
来源：
TETRAHEDRON LETTERS | 2017年 / 58卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Reductive N-benzylation; Ruthenium catalysis; Hydrosilylane; Tertiary amines; TRANSITION-METAL-COMPLEXES; TRANSFER HYDROGENATION; ASYMMETRIC HYDROSILYLATION; EFFICIENT HYDROSILYLATION; RECENT PROGRESS; BOND; HYDROAMINATION; ALCOHOLS; SCOPE;
D O I：
10.1016/j.tetlet.2016.11.112
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The direct reductive N-benzylation of imines by reaction with benzyl bromide derivatives, in the presence of [RuCl2(p-cymene)](2) catalyst and PhSiH3, is performed under mild conditions without additional base. This reaction proceeds by a tandem imine hydrosilylation/nucleophilic substitution with benzyl bromide derivatives to result the tertiary amines. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：137 / 141
页数：5
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