One-pot synthesis of disubstituted imidazole derivatives from α-azido ketones catalyzed by potassium ethylxanthate

被引：22
作者：
Chen, Jun [1 ]
Chen, Wenteng [1 ]
Yu, Yongping [1 ]
Zhang, Guolin [1 ]
机构：
[1] Zhejiang Univ, Coll Pharmaceut Sci, Inst Mat Med, Hangzhou 310058, Zhejiang, Peoples R China
来源：
TETRAHEDRON LETTERS | 2013年 / 54卷 / 12期
关键词：
Disubstituted imidazole; alpha-Azido ketones; Potassium ethylxanthate; Catalyst; Dimerization; MARINE NATURAL-PRODUCTS; BOTRYLLUS-LEACHI; REDUCTION; ALKALOIDS;
D O I：
10.1016/j.tetlet.2013.01.042
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient, novel procedure for the synthesis of new imidazole derivatives from alpha-azido ketones is described. This reaction proceeds via dimerization of aryl glyoxal imino generated from alpha-azido ketones in the presence of potassium ethylxanthate as a catalyst. A possible mechanism for the entire sequence is proposed. (c) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1572 / 1575
页数：4
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