Respiratory Syncytial Virus Infections in Children With Acute Myeloid Leukemia: A Report From the Children's Oncology Group

被引：24

作者：

Sung, Lillian ^{[1
]}

Alonzo, Todd A. ^{[2
,3
]}

Gerbing, Robert B. ^{[2
]}

Aplenc, Richard ^{[4
]}

Lange, Beverly J. ^{[4
]}

Woods, William G. ^{[5
]}

Feusner, James ^{[6
]}

Franklin, Janet ^{[7
,8
]}

Patterson, Maria J. ^{[9
]}

Gamis, Alan S. ^{[10
]}

机构：

[1] Hosp Sick Children, Div Haematol Oncol, Toronto, ON M5G 1X8, Canada

[2] Childrens Oncol Grp, Arcadia, CA USA

[3] Univ So Calif, Div Biostat, Los Angels, CA USA

[4] Childrens Hosp Philadelphia, Div Oncol, Philadelphia, PA 19104 USA

[5] Emory Univ, Childrens Healthcare Atlanta, Aflac Canc Ctr, Atlanta, GA 30322 USA

[6] Childrens Hosp & Res Ctr, Div Hematol Oncol, Oakland, CA USA

[7] Univ So Calif, Dept Pediat, Thousand Oaks, CA USA

[8] Amgen Inc, Thousand Oaks, CA 91320 USA

[9] Michigan State Univ, Dept Microbiol Mol Genet & Pediat, E Lansing, MI 48824 USA

[10] Childrens Mercy Hosp & Clin, Div Hematol Oncol, Kansas City, MO USA

来源：

PEDIATRIC BLOOD & CANCER | 2008年 / 51卷 / 06期

关键词：

acute myeloid leukemia; children; respiratory syncytial virus;

D O I：

10.1002/pbc.21710

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background. Morbidity and mortality related to respiratory syncytial virus (RSV) in pediatric acute myeloid leukemia (AML) is not known. Procedure. We combined data from three Children's Oncology Group AML studies and determined the prevalence of RSV infection and RSV-related mortality in children treated for de novo AML. Results. We found that the prevalence of RSV infection ranged from 0% to 1% in induction and between 0.3 and 2.2% in consolidation. Four children died from RSV resulting in RSV-specific mortality of 0.2% among all children. However, the risk of RSV-related mortality among RSV infection episodes. was high (4/40, 10%). Conclusions. RSV infections and deaths are rare in pediatric AML. Pediatr Blood Cancer 2008;51:784-786. (c) 2008 Wiley-Liss, Inc.

引用

页码：784 / 786

页数：3

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