Synthesis and Characterization of Ionic Liquid Supported on Fe3O4 Nanoparticles and a DFT Study of 1,3-Dipolar Cycloaddition for the Synthesis of Isoxazolidines in the Presence of Ionic Liquid-Fe3O4

A family of novel ionic liquid (IL) with L-alanine and choline chloride as environmentally benign materials has been synthesized and grafted on Fe(3)O(4)nanoparticles (NPs) using easy preparation techniques. The structure of IL supported on Fe(3)O(4)NPs (IL-Fe(3)O(4)NPs) is characterized by various techniques such as field emission scanning electron microscopy (FE-SEM), Energy Dispersive X-Ray (EDX), XRD, Nuclear Magnetic Resonance (NMR), Fourier Transform Infrared (FTIR), and vibrating sample magnetometry (VSM). A stereoselective synthesis of isoxazolidine derivatives in good yields, through a three-component 1,3-dipolar cycloaddition reaction using by IL-Fe(3)O(4)NPs, is reported. The use of IL-Fe(3)O(4)as a catalyst allowed us to prepare diastereoselective isoxazolidine derivatives. Conformational analysis compared with the(1)H NMR data of the products obtained allowed us to determine the absolute configuration. In this paper, the density functional theory (DFT) method with 6-311G (d,p) basis set is employed for solution phase (solvent = CHCl3) of the isoxazolidine derivatives.