Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer

被引：70

作者：

Noh, Sang Jae ^{[1
,2
]}

Baek, Hyun Ah ^{[1
,2
]}

Park, Ho Sung ^{[1
,2
]}

Jang, Kyu Yun ^{[1
,2
]}

Moon, Woo Sung ^{[1
,2
]}

Kang, Myoung Jae ^{[1
,2
]}

Lee, Dong Geun ^{[1
,2
]}

Kim, Min Ho ^{[2
,3
]}

Lee, Ju Hyung ^{[2
,4
]}

Chung, Myoung Ja ^{[1
,2
]}

机构：

[1] Chonbuk Natl Univ, Dept Pathol, Sch Med, Jeonju 561180, South Korea

[2] Res Inst Endocrine Sci, Jeonju 561180, South Korea

[3] Chonbuk Natl Univ, Dept Chest Surg, Sch Med, Jeonju 561180, South Korea

[4] Chonbuk Natl Univ, Dept Prevent Med, Sch Med, Jeonju 561180, South Korea

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2013年 / 209卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

SIRT1; Cortactin; Carcinoma; Non-small cell lung; POOR-PROGNOSIS; TRANSCRIPTION FACTORS; CYCLIN D1; CARCINOMA; AMPLIFICATION; DEACETYLASE; PROTEIN; GENE; EMS1; ADENOCARCINOMA;

D O I：

10.1016/j.prp.2013.03.011

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Cortactin is an F-actin binding protein involved in cell migration and tumor metastasis. Recent reports suggest that silent mating-type information regulation 2 homologue 1 (sirtuinl; SIRT1) enhances the function of cortactin and promotes cell migration. We investigated SIRT1 and cortactin expression in 144 invasive non-small cell lung cancers (NSCLC) and 19 adenocarcinomas in situ (AIS) by immunohistochemistry and evaluated their clinicopathological significance in NSCLC. Positive SIRT1 and cortactin expression was observed in 67% (96 of 144) and 58% (84 of 144) of patients with invasive NSCLC, respectively. SIRT1 and cortactin expression was significantly associated with unfavorable clinicopathological factors, including high pathological T stage, lymph node metastasis, and advanced tumor invasion (AIS vs. invasive adenocarcinoma). Cortactin was significantly associated with high pathological T stage and lymph node metastasis in SIRT1-positive tumors. Cytoplasmic SIRT1 was significantly associated with high pathological T stage and large tumor size compared to that of nuclear SIRT1. Large tumor size, high pathological T stage, lymph node metastasis, and cytoplasmic SIRT1 expression were significantly associated with shorter overall survival in a univariate analysis. Our findings suggest that SIRT1 and cortactin may play a role in the progression of NSCLC and may cooperate during tumor progression in NSCLC. (C) 2013 Elsevier GmbH. All rights reserved.

引用

页码：365 / 370

页数：6

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