Kiwifruit allergy across Europe: Clinical manifestation and IgE recognition patterns to kiwifruit allergens

被引：74

作者：

Le, Thuy-My ^{[1
]}

Bublin, Merima ^{[2
]}

Breiteneder, Heimo ^{[2
]}

Fernandez-Rivas, Montserrat ^{[3
]}

Asero, Riccardo ^{[4
]}

Ballmer-Weber, Barbara ^{[5
]}

Barreales, Laura ^{[3
]}

Bures, Peter ^{[5
]}

Belohlavkova, Simona ^{[6
]}

de Blay, Frederic ^{[7
]}

Clausen, Michael ^{[9
,10
]}

Dubakiene, Ruta ^{[8
]}

Gislason, David ^{[9
,10
]}

van Hoffen, Els ^{[1
]}

Jedrzejczak-Czechowicz, Monika ^{[11
]}

Kowalski, Marek L. ^{[11
]}

Kralimarkova, Tanya ^{[12
]}

Lidholm, Jonas ^{[13
]}

DeWitt, Asa Marknell ^{[13
]}

Mills, Clare E. N. ^{[14
,15
]}

Papadopoulos, Nikolaos G. ^{[16
]}

Popov, Todor ^{[12
]}

Purohit, Ashok ^{[7
]}

van Ree, Ronald ^{[17
,18
]}

Seneviratne, Suranjith ^{[19
]}

Sinaniotis, Athanasios ^{[16
]}

Summers, Colin ^{[20
]}

Vazquez-Cortes, Sonia ^{[3
]}

Vieths, Stefan ^{[21
]}

Vogel, Lothar ^{[21
]}

Hoffmann-Sommergruber, Karin ^{[2
]}

Knulst, Andre C. ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Dermatol Allergol, NL-3508 GA Utrecht, Netherlands

[2] Med Univ Vienna, Dept Pathophysiol & Allergy Res, Vienna, Austria

[3] IdISSC, Hosp Clin San Carlos, Dept Allergy, Madrid, Spain

[4] Clin San Carlo, Paderno Dugnano, Italy

[5] Univ Zurich Hosp, Dept Dermatol, Allergy Unit, Zurich, Switzerland

[6] Fac Hosp Bulovka, Dept Pediat, Prague, Czech Republic

[7] Univ Hosp Strasbourg, Chest Dis Dept, Div Allergy, Strasbourg, France

[8] Vilnius State Univ, Fac Med, Vilnius, Lithuania

[9] Landspitali Univ Hosp, Dept Allergy Resp Med & Sleep, Reykjavik, Iceland

[10] Univ Iceland, Fac Med, Reykjavik, Iceland

[11] Med Univ Lodz, Fac Med, Dept Immunol Rheumatol & Allergy, Lodz, Poland

[12] Med Univ Sofia, Clin Allergy & Asthma, Sofia, Bulgaria

[13] Phadia AB, Uppsala, Sweden

[14] Univ Manchester, Sch Translat Med, Manchester Acad Hlth Sci Ctr, Manchester M13 9PL, Lancs, England

[15] Univ Manchester, Manchester Inst Biotechnol, Manchester M13 9PL, Lancs, England

[16] Univ Athens, Dept Allergy, Pediat Clin 2, GR-10679 Athens, Greece

[17] Univ Amsterdam, Acad Med Ctr, Dept Expt Immunol, NL-1012 WX Amsterdam, Netherlands

[18] Univ Amsterdam, Acad Med Ctr, Dept Otorhinolaryngol, NL-1012 WX Amsterdam, Netherlands

[19] St Marys Hosp, Dept Clin Immunol, London, England

[20] Manchester Royal Infirm, Manchester M13 9WL, Lancs, England

[21] Fed Inst Vaccines & Biomed, Paul Ehrlich Inst, Div Allergol, Langen, Germany

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2013年 / 131卷 / 01期

基金：

奥地利科学基金会; 英国生物技术与生命科学研究理事会;

关键词：

Actinidin; allergens; component resolved diagnosis; diagnosis; food allergy; ImmunoCAP; kiwifruit; skin prick test; LIPID TRANSFER PROTEIN; KIWI FRUIT ALLERGY; SKIN-PRICK-TEST; FOOD ALLERGY; SENSITIZATION PROFILES; CROSS-REACTIVITY; PREVALENCE; ACTINIDIN; HYPERSENSITIVITY; IDENTIFICATION;

D O I：

10.1016/j.jaci.2012.09.009

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background: Kiwifruit is a common cause of food allergy. Symptoms range from mild to anaphylactic reactions. Objective: We sought to elucidate geographic differences across Europe regarding clinical patterns and sensitization to kiwifruit allergens. Factors associated with the severity of kiwifruit allergy were identified, and the diagnostic performance of specific kiwifruit allergens was investigated. Methods: This study was part of EuroPrevall, a multicenter European study investigating several aspects of food allergy. Three hundred eleven patients with kiwifruit allergy from 12 countries representing 4 climatic regions were included. Specific IgE to 6 allergens (Act d 1, Act d 2, Act d 5, Act d 8, Act d 9, and Act d 10) and kiwifruit extract were tested by using ImmunoCAP. Results: Patients from Iceland were mainly sensitized to Act d 1 (32%), those from western/central and eastern Europe were mainly sensitized to Act d 8 (pathogenesis-related class 10 protein, 58% and 44%, respectively), and those from southern Europe were mainly sensitized to Act d 9 (profilin, 31%) and Act d 10 (nonspecific lipid transfer protein, 22%). Sensitization to Act d 1 and living in Iceland were independently and significantly associated with severe kiwifruit allergy (odds ratio, 3.98 [P = 5.003] and 5.60 [P < .001], respectively). Using a panel of 6 kiwifruit allergens in ImmunoCAP increased the diagnostic sensitivity to 65% compared with 20% for skin prick tests and 46% ImmunoCAP using kiwi extract. Conclusion: Kiwifruit allergen sensitization patterns differ across Europe. The use of specific kiwifruit allergens improved the diagnostic performance compared with kiwifruit extract. Sensitization to Act d 1 and living in Iceland are strong risk factors for severe kiwifruit allergy. (J Allergy Clin Immunol 2013;131:164-71.)

引用

页码：164 / 171

页数：8

共 45 条

[1] Allergy to kiwi:: A double-blind, placebo-controlled food challenge study in patients from a birch-free area [J].

Alemán, A ;

Sastre, J ;

Quirce, S ;

de las Heras, M ;

Carnés, J ;

Fernández-Caldas, E ;

Pastor, C ;

Blázquez, AB ;

Vivanco, F ;

Cuesta-Herranz, J .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2004, 113 (03) :543-550

[2] Profilin sensitization detected in the office by skin prick test: a study of prevalence and clinical relevance of profilin as a plant food allergen [J].

Asero, R. ;

Monsalve, R. ;

Barber, D. .

CLINICAL AND EXPERIMENTAL ALLERGY, 2008, 38 (06) :1033-1037

[3] Lipid transfer protein: A pan-allergen in plant-derived foods that is highly resistant to pepsin digestion [J].

Asero, R ;

Mistrello, G ;

Roncarolo, D ;

de Vries, SC ;

Gautier, MF ;

Ciurana, CLF ;

Verbeek, E ;

Mohammadi, T ;

Knul-Brettlova, V ;

Akkerdaas, JH ;

Bulder, I ;

Aalberse, RC ;

van Ree, R .

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2001, 124 (1-3) :67-69

[4] IgE-Mediated food allergy diagnosis: Current status and new perspectives [J].

Asero, Riccardo ;

Ballmer-Weber, Barbara K. ;

Beyer, Kirsten ;

Conti, Amedeo ;

Dubakiene, Ruta ;

Fernandez-Rivas, Montserrat ;

Hoffmann-Sommergruber, Karin ;

Lidholm, Jonas ;

Mustakov, Tihomir ;

Elberink, Joanne N. G. Oude ;

Pumphrey, Richard S. H. ;

Skov, Per Stahl ;

van Ree, Ronald ;

Vlieg-Boerstra, Berber J. ;

Hiller, Reinhard ;

Hourihane, Jonathan O. ;

Kowalski, Marek ;

Papadopoulos, Nikos G. ;

Wal, Jean-Michel ;

Mills, E. N. Clare ;

Vieths, Stefan .

MOLECULAR NUTRITION & FOOD RESEARCH, 2007, 51 (01) :135-147

[5] Standardization of food challenges in patients with immediate reactions to foods - position paper from the European Academy of Allergology and Clinical Immunology [J].

Bindslev-Jensen, C ;

Ballmer-Weber, BK ;

Bengtsson, U ;

Blanco, C ;

Ebner, C ;

Hourihane, J ;

Knulst, AC ;

Moneret-Vautrin, DA ;

Nekam, K ;

Niggemann, B ;

Osterballe, M ;

Ortolani, C ;

Ring, J ;

Schnopp, C ;

Werfel, T .

ALLERGY, 2004, 59 (07) :690-697

[6] Geographical variation in the prevalence of positive skin tests to environmental aeroallergens in the European Community Respiratory Health Survey I [J].

Bousquet, P. -J. ;

Chinn, S. ;

Janson, C. ;

Kogevinas, M. ;

Burney, P. ;

Jarvis, D. .

ALLERGY, 2007, 62 (03) :301-309

[7] DIFFERENCES IN THE INTERACTIONS OF THE CATALYTIC GROUPS OF THE ACTIVE-CENTERS OF ACTINIDIN AND PAPAIN - RAPID PURIFICATION OF FULLY ACTIVE ACTINIDIN BY COVALENT CHROMATOGRAPHY AND CHARACTERIZATION OF ITS ACTIVE-CENTER BY USE OF 2-PROTONIC-STATE REACTIVITY PROBES [J].

BROCKLEHURST, K ;

BAINES, BS ;

MALTHOUSE, JPG .

BIOCHEMICAL JOURNAL, 1981, 197 (03) :739-746

[8] Climate-vegetation interaction [J].

Brovkin, V .

JOURNAL DE PHYSIQUE IV, 2002, 12 (PR10) :57-72

[9] IgE sensitization profiles toward green and gold kiwifruits differ among patients allergic to kiwifruit from 3 European countries [J].

Bublin, M ;

Mari, A ;

Ebner, C ;

Knulst, A ;

Scheiner, O ;

Hoffmann-Sommergruber, K ;

Breiteneder, H ;

Radauer, C .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2004, 114 (05) :1169-1175

[10] The performance of a component-based allergen microarray for the diagnosis of kiwifruit allergy [J].

Bublin, M. ;

Dennstedt, S. ;

Buchegger, M. ;

Ciardiello, M. Antonietta ;

Bernardi, M. L. ;

Tuppo, L. ;

Harwanegg, C. ;

Hafner, C. ;

Ebner, C. ;

Ballmer-Weber, B. K. ;

Knulst, A. ;

Hoffmann-Sommergruber, K. ;

Radauer, C. ;

Mari, A. ;

Breiteneder, H. .

CLINICAL AND EXPERIMENTAL ALLERGY, 2011, 41 (01) :129-136

← 1 2 3 4 5 →