Electrospun poly(lactic acid)/chitosan core-shell structure nanofibers from homogeneous solution

被引：74

作者：

Li, Yajing ^{[1
]}

Chen, Fan ^{[1
]}

Nie, Jun ^{[1
]}

Yang, Dongzhi ^{[1
]}

机构：

[1] Beijing Univ Chem Technol, Key Lab Beijing City Preparat & Proc Novel Polyme, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2012年 / 90卷 / 04期

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

Core-shell structure; Electrospinning; Poly(lactic acid); Homogeneous solution; Chitosan; POLYMER NANOFIBERS; CHITOSAN; SCAFFOLDS; MATS; FABRICATION; MORPHOLOGY; SKIN;

D O I：

10.1016/j.carbpol.2012.07.013

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The core-shell structure nanofibers of poly(lactic acid)/chitosan with different weight ratios were successfully electrospun from homogeneous solution. The preparation process was more simple and effective than double-needle electrospinning. The nanofibers were obtained with chitosan in shell while poly(lactic acid) in core attributing to phase separation, which were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM). X-ray diffraction (XRD) and energy dispersive spectrometer (EDS). The electrospun nanofibrous membrane was evaluated in vitro by using mouse fibroblasts (L929) as reference cell lines. Cell culture results indicated that these materials were good in promoting cell growth and attachment, thus they could be used for tissue engineering and wound healing dressing. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1445 / 1451

页数：7

共 23 条

[1] Chitosan derivatives obtained by chemical modifications for biomedical and environmental applications [J].

Alves, N. M. ;

Mano, J. F. .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2008, 43 (05) :401-414

[2] Electrospinning: A fascinating fiber fabrication technique [J].

Bhardwaj, Nandana ;

Kundu, Subhas C. .

BIOTECHNOLOGY ADVANCES, 2010, 28 (03) :325-347

[3] Novel nanocomposites and nanoceramics based on polymer nanofibers using electrospinning process - A review [J].

Chronakis, IS .

JOURNAL OF MATERIALS PROCESSING TECHNOLOGY, 2005, 167 (2-3) :283-293

[4] Encapsulating drugs in biodegradable ultrafine fibers through co-axial electrospinning [J].

Huang, ZM ;

He, CL ;

Yang, AZ ;

Zhang, YZ ;

Hang, XJ ;

Yin, JL ;

Wu, QS .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2006, 77A (01) :169-179

[5] Electrospun Non-Woven Nanofibrous Hybrid Mats Based on Chitosan and PLA for Wound-Dressing Applications [J].

Ignatova, Milena ;

Manolova, Nevena ;

Markova, Nadya ;

Rashkov, Iliya .

MACROMOLECULAR BIOSCIENCE, 2009, 9 (01) :102-111

[6] Electrospun Nanofibrous Mats Containing Quaternized Chitosan and Polylactide with In Vitro Antitumor Activity against HeLa Cells [J].

Ignatova, Milena G. ;

Manolova, Nevena E. ;

Toshkova, Reneta A. ;

Rashkov, Iliya B. ;

Gardeva, Elena G. ;

Yossifova, Lilia S. ;

Alexandrov, Marin T. .

BIOMACROMOLECULES, 2010, 11 (06) :1633-1645

[7] Fabrication and characterization of poly (vinyl alcohol)/chitosan blend nanofibers produced by electrospinning method [J].

Jia, Yong-Tang ;

Gong, Jian ;

Gu, Xiao-Hua ;

Kim, Hark-Yong ;

Dong, Jiong ;

Shen, Xin-Yuan .

CARBOHYDRATE POLYMERS, 2007, 67 (03) :403-409

[8] Functional electrospun nanofibrous scaffolds for biomedical applications [J].

Liang, Dehai ;

Hsiao, Benjamin S. ;

Chu, Benjamin .

ADVANCED DRUG DELIVERY REVIEWS, 2007, 59 (14) :1392-1412

[9] Progress and opportunities for tissue-engineered skin [J].

MacNeil, Sheila .

NATURE, 2007, 445 (7130) :874-880

[10] Natural origin biodegradable systems in tissue engineering and regenerative medicine: present status and some moving trends [J].

Mano, J. F. ;

Silva, G. A. ;

Azevedo, H. S. ;

Malafaya, P. B. ;

Sousa, R. A. ;

Silva, S. S. ;

Boesel, L. F. ;

Oliveira, J. M. ;

Santos, T. C. ;

Marques, A. P. ;

Neves, N. M. ;

Reis, R. L. .

JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2007, 4 (17) :999-1030

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