Foxp3 and Treg cells in HIV-1 infection and immuno-pathogenesis

被引：41

作者：

Holmes, Derek ^{[1
]}

Jiang, Qi ^{[1
]}

Zhang, Liguo ^{[1
]}

Su, Lishan ^{[1
]}

机构：

[1] Univ N Carolina, Sch Med, Lineberger Comprehens Canc Ctr, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

来源：

IMMUNOLOGIC RESEARCH | 2008年 / 41卷 / 03期

关键词：

regulatory T cells; AIDS; chromatin; epigenetic; humanized mouse; DKO-hu; ONTAK;

D O I：

10.1007/s12026-008-8037-x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

FoxP3(+) CD4(+) CD25(+) regulatory T (Treg) cells are implicated in a number of pathologic processes including elevated levels in cancers and infectious diseases, and reduced levels in autoimmune diseases. Treg cells are activated to modulate immune responses to avoid over-reactive immunity. However, conflicting findings are reported regarding relative levels of Treg cells during HIV-1 infection and disease progression. The role of Treg cells in HIV-1 diseases (aberrant immune activation) is poorly understood due to lack of a robust model. We summarize here the regulation and function of Foxp3 in Treg cells and in modulating HIV-1 replication. Based on recent findings from SIV/monkey and HIV/humanized mouse models, a model of the dual role of Treg cells in HIV-1 infection and immuno-pathogenesis is discussed.

引用

页码：248 / 266

页数：19

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