Association between TNFα-308 G/A polymorphism and oral lichen planus (OLP): a meta-analysis

被引:12
作者
Zhou, Yuqiao [1 ,2 ]
Vieira, Alexandre Rezende [2 ]
机构
[1] Sichuan Univ, West China Coll Stomatol, State Key Lab Oral Dis, Chengdu, Sichuan, Peoples R China
[2] Univ Pittsburgh, Sch Dent Med, Dept Oral Biol, Pittsburgh, PA 15261 USA
关键词
Oral lichen planus; Tumor necrosis factors; Genetic polymorphism; TUMOR-NECROSIS-FACTOR; CYTOKINE GENE POLYMORPHISMS; TNF-ALPHA GENE; SUSCEPTIBILITY; INTERLEUKIN-10; RISK; BETA;
D O I
10.1590/1678-7757-2017-0184
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Objectives: To determine whether Tumor Necrosis Factor alpha (TNF alpha) -308 G/A polymorphism is associated with oral lichen planus (OLP). Material and Methods: A systematic electronic search of the literature was conducted to identify all published studies on the association between TNF alpha -308 G/A polymorphism and OLP. All case-control studies evaluating the TNF alpha -308 G/A polymorphisms in OLP were selected. A meta-analysis of the studies that fulfilled the inclusion criteria was performed. Odds ratios (OR) with 95% confidence intervals (CI) were also calculated. Results: Seven studies comprising 450 OLP cases and 867 controls were included in the meta-analysis. In the pooled analysis, TNF alpha -308 G/A polymorphism was associated with OLP with random effects and OR of 2.33 (95% CI=1.07-5.11; p=0.03), assuming a dominant mode of inheritance (AA+GA vs. GG). In the subgroup analysis by ethnicity, TNF alpha -308 G/A was associated with a significantly increased odds ratio of OLP in mixed ethnicity (OR=5.22; 95% CI=1.93-14.15; p=0.001), but not in Asians (OR=1.57; 95% CI=0.54-4.54; p=0.41) or Caucasians (OR=1.45; 95% CI=0.19-11.22; p=0.72). For subgroup analysis based on HCV (hepatitis C virus) infection status, significant increased risk of OLP was found among patients with mixed HCV infection status (OR=3.77; 95% CI=1.07-13.2; p=0.038), but not in patients without HCV infection (OR=2.09; 95% CI=0.63-6.91; p=0.22) and patients with HCV infection (OR=0.48; 95% CI=0.13-1.69; p=0.25). Conclusion: Our results suggest that -308 G/A polymorphism in TNF alpha is a potential genetic marker for OLP.
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页数:8
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