Theta bursts set up glutamatergic as well as GABA-ergic plasticity in neonatal rat hippocampal CA1 neurons

被引：7

作者：

Ouardouz, M ^{[1
]}

Xu, JY ^{[1
]}

Sastry, BR ^{[1
]}

机构：

[1] Univ British Columbia, Fac Med, Dept Pharmacol & Therapeut, Neurosci Res Lab, Vancouver, BC V6T 1Z3, Canada

来源：

BRAIN RESEARCH | 2006年 / 1068卷 / 01期

关键词：

GABA; reversal potential; plasticity; hippocampal CA1 neuron; inhibitory postsynaptic current; theta burst; AMPA;

D O I：

10.1016/j.brainres.2005.10.089

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

gamma-Aminobutyric acid (GABA) is inhibitory in adult, but excitatory in neonatal, neurons. The switch from excitatory to inhibitory action is due to a negative shift in the equilibrium potential for the GABA(A) receptor-mediated postsynaptic current (EGABA-PSC). Here, we report that, in neonatal rat hippocampal CA1 neurons, presynaptic theta-burst activation induces not only a shift in EGABA-PSC towards that in adult neurons, but also a recruitment of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-receptor-mediated postsynaptic currents. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：65 / 69

页数：5

共 19 条

[1] GABA(A), NMDA and AMPA receptors: a developmentally regulated 'menage a trois' [J].