Translational Bioinformatics: Data-driven Drug Discovery and Development

被引:14
作者
Butte, A. J. [1 ,2 ]
Ito, S. [3 ]
机构
[1] Stanford Univ, Dept Pediat, Sch Med, Div Syst Med, Stanford, CA 94305 USA
[2] Lucile Packard Childrens Hosp, Palo Alto, CA USA
[3] Hosp Sick Children, Div Clin Pharmacol & Toxicol, Toronto, ON M5G 1X8, Canada
关键词
D O I
10.1038/clpt.2012.55
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Internet-accessible computing power and data-sharing mandates now enable researchers to interrogate thousands of publicly available databases containing molecular, clinical, and epidemiological data. With emerging new approaches, translational bioinformatics can now provide answers to previously untouchable questions, ranging from detecting population signals of adverse drug reactions to clinical interpretation of the whole genome. There are challenges, including lack of access to some data sources and software, but there are also overwhelming doses of hopes and expectations.
引用
收藏
页码:949 / 952
页数:4
相关论文
共 50 条
  • [21] Data-driven translational prostate cancer research: from biomarker discovery to clinical decision
    Yuxin Lin
    Xiaojun Zhao
    Zhijun Miao
    Zhixin Ling
    Xuedong Wei
    Jinxian Pu
    Jianquan Hou
    Bairong Shen
    Journal of Translational Medicine, 18
  • [22] Data-driven discovery of quasiperiodically driven dynamics
    Das, Suddhasattwa
    Mustavee, Shakib
    Agarwal, Shaurya
    NONLINEAR DYNAMICS, 2025, 113 (05) : 4097 - 4120
  • [23] Data-driven drug discovery for rare diseases: tales from the trenches
    van den Broek, Frederik
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 257
  • [24] Data-driven translational prostate cancer research: from biomarker discovery to clinical decision
    Lin, Yuxin
    Zhao, Xiaojun
    Miao, Zhijun
    Ling, Zhixin
    Wei, Xuedong
    Pu, Jinxian
    Hou, Jianquan
    Shen, Bairong
    JOURNAL OF TRANSLATIONAL MEDICINE, 2020, 18 (01)
  • [25] The Rise of Bioinformatics in Data-driven Cancer Research
    Bork, P.
    EUROPEAN JOURNAL OF CANCER, 2012, 48 : S13 - S13
  • [26] Editorial: Bioinformatics and the Translation of Data-Driven Discoveries
    Khan, Asif M.
    Ranganathan, Shoba
    Suravajhala, Prashanth
    FRONTIERS IN GENETICS, 2022, 13
  • [27] Bioinformatics: scalability, capabilities and training in the data-driven
    Schneider, Maria Victoria
    Jimenez, Rafael C.
    BRIEFINGS IN BIOINFORMATICS, 2019, 20 (02) : 735 - 736
  • [28] Computational Data-Driven Materials Discovery
    Mannodi-Kanakkithodi, Arun
    Chan, Maria K. Y.
    TRENDS IN CHEMISTRY, 2021, 3 (02): : 79 - 82
  • [29] Data-driven discovery of causal interactions
    Ma, Saisai
    Liu, Lin
    Li, Jiuyong
    Thuc Duy Le
    INTERNATIONAL JOURNAL OF DATA SCIENCE AND ANALYTICS, 2019, 8 (03) : 285 - 297
  • [30] Data-Driven Discovery of Closure Models
    Pan, Shaowu
    Duraisamy, Karthik
    SIAM JOURNAL ON APPLIED DYNAMICAL SYSTEMS, 2018, 17 (04): : 2381 - 2413