Microbubble-sonosensitiser conjugates as therapeutics in sonodynamic therapy

被引：68

作者：

Nomikou, Nikolitsa ^{[2
]}

Fowley, Colin ^{[1
]}

Byrne, Niall M. ^{[1
]}

McCaughan, Bridgeen ^{[1
]}

McHale, Anthony P. ^{[1
]}

Callan, John F. ^{[1
]}

机构：

[1] Univ Ulster, Sch Biomed Sci, Dept Pharm & Pharmaceut Sci, Coleraine BT52 1SA, Londonderry, North Ireland

[2] Sonidel Ltd, Dublin 5, Ireland

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 67期

关键词：

ROSE-BENGAL; ULTRASOUND; GENE; DRUG; SONOLUMINESCENCE; DESTRUCTION;

D O I：

10.1039/c2cc33913g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A Rose Bengal sonosensitiser has been covalently attached to a lipid microbubble and the resulting conjugate shown to produce higher levels of singlet oxygen, enhanced cytotoxicity in a cancer cell line and a greater reduction in tumour growth than the sonosensitiser alone.

引用

页码：8332 / 8334

页数：3

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