Isolation and chromosomal assignment of a human gene encoding protein inhibitor of activated STAT3 (PIAS3)

被引：10
作者：
Ueki, N
Seki, N
Yano, K
Saito, T
Masuho, Y
Muramatsu, M
机构：
[1] Helix Res Inst, Chiba 2920812, Japan
[2] Kazusa DNA Res Inst, Chiba, Japan
[3] Natl Inst Radiol Sci, Genome Res Grp, Chiba 260, Japan
[4] Tokyo Med & Dent Univ, Med Res Inst, Dept Biol Cybernet, Tokyo, Japan
来源：
JOURNAL OF HUMAN GENETICS | 1999年 / 44卷 / 03期
关键词：
STAT3; PIAS3; cytokine; transcription factor; hematopoiesis; 1q21;
D O I：
10.1007/s100380050141
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Mouse PIAS3 (protein inhibitor of activated STAT3) is a specific inhibitor of STAT3 that downregulates its signaling pathway. Here we report the isolation and chromosome mapping of the human PIAS3 gene. Human PIAS3 cDNA encoded a predicted protein of 619 aa which has 83% overall amino acid identity to the mouse counterpart. Based on polymerase chain reaction assisted analysis of a human/rodent mono-chromosomal hybrid cell panel and a radiation hybrid mapping panel, the human PIAS3 gene was mapped to the chromosome 1q21 region. Mapping of a crucial gene in modulating the STAT-3 signaling pathway may provide new clues to the understanding of malignancies or genetic disorders caused by this chromosome region.
引用
收藏
页码：193 / 196
页数：4
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