The prognostic potential of long noncoding RNA HOTAIR expression in human digestive system carcinomas: A meta-analysis

被引：26
作者：
Abdeahad, Hossein [1 ]
Avan, Amir [2 ,3 ]
Pashirzad, Mehran [1 ]
Khazaei, Majid [2 ,4 ]
Soleimanpour, Saman [5 ]
Ferns, Gordon A. [6 ]
Fiuji, Hamid [7 ]
Ryzhikov, Mikhail [8 ]
Bahrami, Afsane [9 ]
Hassanian, Seyed Mahdi [1 ,2 ]
机构：
[1] Mashhad Univ Med Sci, Dept Clin Biochem, Fac Med, Mashhad, Razavi Khorasan, Iran
[2] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Razavi Khorasan, Iran
[3] Mashhad Univ Med Sci, Dept Modern Sci & Technol, Fac Med, Mashhad, Razavi Khorasan, Iran
[4] Mashhad Univ Med Sci, Dept Med Physiol, Fac Med, Mashhad, Razavi Khorasan, Iran
[5] Mashhad Univ Med Sci, Sch Med, Dept Microbiol & Virol, Mashhad, Razavi Khorasan, Iran
[6] Brighton & Sussex Med Sch, Div Med Educ, Brighton, E Sussex, England
[7] Payame Noor Univ, Dept Biochem, Mashhad, Razavi Khorasan, Iran
[8] Washington Univ, Sch Med, Div Pulm & Crit Care Med, St Louis, MO USA
[9] Birjand Univ Med Sci, Cellular & Mol Res Ctr, Birjand, Iran
来源：
JOURNAL OF CELLULAR PHYSIOLOGY | 2019年 / 234卷 / 07期
关键词：
digestive system carcinomas; HOTAIR; overall survival; prognostic biomarker; TUMOR-METASTASIS; CERVICAL-CANCER; POOR-PROGNOSIS; PREDICTS; OVEREXPRESSION; PROLIFERATION; SURVIVAL; INVASION; MARKER;
D O I：
10.1002/jcp.27918
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Homeobox transcript antisense intergenic RNA (HOTAIR), one of the well-known long noncoding RNAs (lncRNAs), plays an important role in initiation and development of various tumors. Elevated level of HOTAIR is associated with metastatic behavior of primary tumor and poor outcome in several cancers. Therefore, we conducted a meta-analysis to clearly measure the prognostic impact of HOTAIR in patients with digestive system carcinomas. Fourteen studies including 2,666 patients with five different type of digestive system cancers were selected to be entered in meta-analysis. Finding demonstrated that HOTAIR overexpression could predict unfavorable outcome in digestive system carcinomas (hazard ratio [HR]=2.4, 95% confidence interval [CI]: 2.0-2.9; p<0.001; fixed-effect model). In stratified analysis, increased level of HOTAIR predicted poor overall survival in gastric cancer (HR=2.1, 95% CI: 1.6-2.9; p<0.001), colorectal cancer (HR=4.1, 95% CI: 1.6-10.2; p=0.002), esophageal squamous cell carcinoma (HR=2.3, 95% CI: 1.7-3.0; p<0.001), and hepatocellular carcinoma (HR=3.4, 95% CI: 1.9-6.1; p<0.001). Our meta-analysis results clearly support the prognostic value of HOTAIR to predict unfavorable prognostic outcomes in diverse digestive system carcinomas.
引用
收藏
页码：10926 / 10933
页数：8
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