The prognostic potential of long noncoding RNA HOTAIR expression in human digestive system carcinomas: A meta-analysis

被引:26
作者
Abdeahad, Hossein [1 ]
Avan, Amir [2 ,3 ]
Pashirzad, Mehran [1 ]
Khazaei, Majid [2 ,4 ]
Soleimanpour, Saman [5 ]
Ferns, Gordon A. [6 ]
Fiuji, Hamid [7 ]
Ryzhikov, Mikhail [8 ]
Bahrami, Afsane [9 ]
Hassanian, Seyed Mahdi [1 ,2 ]
机构
[1] Mashhad Univ Med Sci, Dept Clin Biochem, Fac Med, Mashhad, Razavi Khorasan, Iran
[2] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Razavi Khorasan, Iran
[3] Mashhad Univ Med Sci, Dept Modern Sci & Technol, Fac Med, Mashhad, Razavi Khorasan, Iran
[4] Mashhad Univ Med Sci, Dept Med Physiol, Fac Med, Mashhad, Razavi Khorasan, Iran
[5] Mashhad Univ Med Sci, Sch Med, Dept Microbiol & Virol, Mashhad, Razavi Khorasan, Iran
[6] Brighton & Sussex Med Sch, Div Med Educ, Brighton, E Sussex, England
[7] Payame Noor Univ, Dept Biochem, Mashhad, Razavi Khorasan, Iran
[8] Washington Univ, Sch Med, Div Pulm & Crit Care Med, St Louis, MO USA
[9] Birjand Univ Med Sci, Cellular & Mol Res Ctr, Birjand, Iran
关键词
digestive system carcinomas; HOTAIR; overall survival; prognostic biomarker; TUMOR-METASTASIS; CERVICAL-CANCER; POOR-PROGNOSIS; PREDICTS; OVEREXPRESSION; PROLIFERATION; SURVIVAL; INVASION; MARKER;
D O I
10.1002/jcp.27918
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Homeobox transcript antisense intergenic RNA (HOTAIR), one of the well-known long noncoding RNAs (lncRNAs), plays an important role in initiation and development of various tumors. Elevated level of HOTAIR is associated with metastatic behavior of primary tumor and poor outcome in several cancers. Therefore, we conducted a meta-analysis to clearly measure the prognostic impact of HOTAIR in patients with digestive system carcinomas. Fourteen studies including 2,666 patients with five different type of digestive system cancers were selected to be entered in meta-analysis. Finding demonstrated that HOTAIR overexpression could predict unfavorable outcome in digestive system carcinomas (hazard ratio [HR]=2.4, 95% confidence interval [CI]: 2.0-2.9; p<0.001; fixed-effect model). In stratified analysis, increased level of HOTAIR predicted poor overall survival in gastric cancer (HR=2.1, 95% CI: 1.6-2.9; p<0.001), colorectal cancer (HR=4.1, 95% CI: 1.6-10.2; p=0.002), esophageal squamous cell carcinoma (HR=2.3, 95% CI: 1.7-3.0; p<0.001), and hepatocellular carcinoma (HR=3.4, 95% CI: 1.9-6.1; p<0.001). Our meta-analysis results clearly support the prognostic value of HOTAIR to predict unfavorable prognostic outcomes in diverse digestive system carcinomas.
引用
收藏
页码:10926 / 10933
页数:8
相关论文
共 54 条
[1]  
Borenstein M., 2005, COMPREHENSIVE META A
[2]   Genistein Inhibits Prostate Cancer Cell Growth by Targeting miR-34a and Oncogenic HOTAIR [J].
Chiyomaru, Takeshi ;
Yamamura, Soichiro ;
Fukuhara, Shinichiro ;
Yoshino, Hirofumi ;
Kinoshita, Takashi ;
Majid, Shahana ;
Saini, Sharanjot ;
Chang, Inik ;
Tanaka, Yuichiro ;
Enokida, Hideki ;
Seki, Naohiko ;
Nakagawa, Masayuki ;
Dahiya, Rajvir .
PLOS ONE, 2013, 8 (08)
[3]   METAANALYSIS IN CLINICAL-TRIALS [J].
DERSIMONIAN, R ;
LAIRD, N .
CONTROLLED CLINICAL TRIALS, 1986, 7 (03) :177-188
[4]   Databases for lncRNAs: a comparative evaluation of emerging tools [J].
Fritah, Sabrina ;
Niclou, Simone P. ;
Azuaje, Francisco .
RNA, 2014, 20 (11) :1655-1665
[5]   HOTAIR, a prognostic factor in esophageal squamous cell carcinoma, inhibits WIF-1 expression and activates Wnt pathway [J].
Ge, Xiao-Song ;
Ma, Hua-Juan ;
Zheng, Xiao-Hui ;
Ruan, Hong-Lian ;
Liao, Xiao-Yu ;
Xue, Wen-Qiong ;
Chen, Yuan-Bin ;
Zhang, Ying ;
Jia, Wei-Hua .
CANCER SCIENCE, 2013, 104 (12) :1675-1682
[6]   Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis [J].
Gupta, Rajnish A. ;
Shah, Nilay ;
Wang, Kevin C. ;
Kim, Jeewon ;
Horlings, Hugo M. ;
Wong, David J. ;
Tsai, Miao-Chih ;
Hung, Tiffany ;
Argani, Pedram ;
Rinn, John L. ;
Wang, Yulei ;
Brzoska, Pius ;
Kong, Benjamin ;
Li, Rui ;
West, Robert B. ;
van de Vijver, Marc J. ;
Sukumar, Saraswati ;
Chang, Howard Y. .
NATURE, 2010, 464 (7291) :1071-U148
[7]   Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals [J].
Guttman, Mitchell ;
Amit, Ido ;
Garber, Manuel ;
French, Courtney ;
Lin, Michael F. ;
Feldser, David ;
Huarte, Maite ;
Zuk, Or ;
Carey, Bryce W. ;
Cassady, John P. ;
Cabili, Moran N. ;
Jaenisch, Rudolf ;
Mikkelsen, Tarjei S. ;
Jacks, Tyler ;
Hacohen, Nir ;
Bernstein, Bradley E. ;
Kellis, Manolis ;
Regev, Aviv ;
Rinn, John L. ;
Lander, Eric S. .
NATURE, 2009, 458 (7235) :223-227
[8]  
Hajjari Mohammadreza, 2013, Frontiers in Genetics, V4, P250, DOI 10.3389/fgene.2013.00250
[9]   The long non-coding RNA HOTAIR is upregulated in endometrial carcinoma and correlates with poor prognosis [J].
He, Xiaoying ;
Bao, Wei ;
Li, Xiaocui ;
Chen, Zheng ;
Che, Qi ;
Wang, Huihui ;
Wan, Xiao-Ping .
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2014, 33 (02) :325-332
[10]   The long noncoding RNA HOTAIR has tissue and cell type-dependent effects on HOX gene expression and phenotype of urothelial cancer cells [J].
Heubach, Judith ;
Monsior, Juliana ;
Deenen, Rene ;
Niegisch, Guenter ;
Szarvas, Tibor ;
Niedworok, Christian ;
Schulz, Wolfgang Arthur ;
Hoffmann, Michele Janine .
MOLECULAR CANCER, 2015, 14