Immunostimulatory colloidal delivery systems for cancer vaccines

被引：26
作者：
Saupe, Anne [1 ]
McBurney, Warren [1 ]
Rades, Thomas [1 ]
Hook, Sarah [1 ]
机构：
[1] Univ Otago, Sch Pharm, Dunedin, New Zealand
来源：
EXPERT OPINION ON DRUG DELIVERY | 2006年 / 3卷 / 03期
关键词：
archaeosomes; cancer vaccine delivery; colloidal systems; immune stimulating complexes; liposomes; polymeric microparticles; polymeric nanoparticles; virus-like particles;
D O I：
10.1517/17425247.3.3.345
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cancer vaccine delivery is a multidisciplinary scientific field that is currently undergoing rapid development. An important component of cancer vaccines is the development of novel vaccine delivery strategies, such as colloidal immunostimulatory delivery systems. The importance of formulation strategies for cancer vaccines can be explained by the poor immunogenicity of tumour antigens. Colloidal vaccine delivery systems modify the kinetics, body distribution, uptake and release of the vaccine. This review explores recent research that is directed towards more targeted treatments of cancer through to colloidal vaccine delivery systems. Widely investigated carrier systems include polymeric micro-and nanoparticles, liposomes, archaeal lipid liposomes (archaeosomes), immune-stimulating complexes and virus-like particles. These systems are evaluated in terms of their formulation techniques, immunological mechanisms of action as well as the potential and limitations of such colloidal systems in the field of cancer vaccines.
引用
收藏
页码：345 / 354
页数：10
相关论文
共 93 条
[41]   PHAGOCYTOSIS OF LATEX-PARTICLES BY LEUKOCYTES .1. DEPENDENCE OF PHAGOCYTOSIS ON THE SIZE AND SURFACE-POTENTIAL OF PARTICLES [J].
KAWAGUCHI, H ;
KOIWAI, N ;
OHTSUKA, Y ;
MIYAMOTO, M ;
SASAKAWA, S .
BIOMATERIALS, 1986, 7 (01) :61-66
[42]   Formulation and biopharmaceutical issues in the development of drug delivery systems for antiparasitic drugs [J].
Kayser, O ;
Olbrich, C ;
Croft, SL ;
Kiderlen, AF .
PARASITOLOGY RESEARCH, 2003, 90 (Suppl 2) :S63-S70
[43]   Special methods for the analysis of ether lipid structure and metabolism in archaea [J].
Koga, Y ;
Morii, H .
ANALYTICAL BIOCHEMISTRY, 2006, 348 (01) :1-14
[44]   Using different structure types of microemulsions for the preparation of poly(alkylcyanoacrylate) nanoparticles by interfacial polymerization [J].
Krauel, K ;
Davies, NM ;
Hook, S ;
Rades, T .
JOURNAL OF CONTROLLED RELEASE, 2005, 106 (1-2) :76-87
[45]   ANALYSIS OF PROTEIN EXPRESSION AND VIRUS-LIKE PARTICLE FORMATION IN MAMMALIAN-CELL LINES STABLY EXPRESSING HIV-1 GAG AND ENV GENE-PRODUCTS WITH OR WITHOUT ACTIVE HIV PROTEINASE [J].
KRAUSSLICH, HG ;
OCHSENBAUER, C ;
TRAENCKNER, AM ;
MERGENER, K ;
FACKE, M ;
GELDERBLOM, HR ;
BOSCH, V .
VIROLOGY, 1993, 192 (02) :605-617
[46]   Archaeosome vaccine adjuvants induce strong humoral, cell-mediated, and memory responses: Comparison to conventional liposomes and alum [J].
Krishnan, L ;
Dicaire, CJ ;
Patel, GB ;
Sprott, GD .
INFECTION AND IMMUNITY, 2000, 68 (01) :54-63
[47]   Enhanced antigen presentation and immunostimulation of dendritic cells using acid-degradable cationic nanoparticles [J].
Kwon, YJ ;
Standley, SM ;
Goh, SL ;
Fréchet, JMJ .
JOURNAL OF CONTROLLED RELEASE, 2005, 105 (03) :199-212
[48]   VESICLES FROM MIXTURES OF BIPOLAR ARCHAEBACTERIAL LIPIDS WITH EGG PHOSPHATIDYLCHOLINE [J].
LELKES, PI ;
GOLDENBERG, D ;
GLIOZZI, A ;
DEROSA, M ;
GAMBACORTA, A ;
MILLER, IR .
BIOCHIMICA ET BIOPHYSICA ACTA, 1983, 732 (03) :714-718
[49]   ISCOM® based vaccines for cancer immunotherapy [J].
Lenarczyk, A ;
Le, TTT ;
Drane, D ;
Malliaros, J ;
Pearse, M ;
Hamilton, R ;
Cox, J ;
Luft, T ;
Gardner, J ;
Suhrbier, A .
VACCINE, 2004, 22 (08) :963-974
[50]   Immuno-stimulating complexes prepared by ethanol injection [J].
Lendemans, DG ;
Myschik, J ;
Hook, S ;
Rades, T .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 2005, 57 (06) :729-733
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