Spatial Propagation of Protein Polymerization

被引：19

作者：

Cohen, S. I. A. ^{[1
,2
]}

Rajah, L. ^{[1
]}

Yoon, C. H. ^{[1
]}

Buell, A. K. ^{[1
]}

White, D. A. ^{[1
]}

Sperling, R. A. ^{[2
]}

Vendruscolo, M. ^{[1
]}

Terentjev, E. M. ^{[3
]}

Dobson, C. M. ^{[1
]}

Weitz, D. A. ^{[2
,4
]}

Knowles, T. P. J. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[2] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA

[3] Univ Cambridge, Cavendish Lab, Cambridge CB3 0HE, England

[4] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA

来源：

PHYSICAL REVIEW LETTERS | 2014年 / 112卷 / 09期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;

关键词：

NUCLEATED CONFORMATIONAL CONVERSION; DIFFUSION-LIMITED AGGREGATION; DISEASE; NEURODEGENERATION; TRANSMISSION; KINETICS; FIBRILS; FORMS;

D O I：

10.1103/PhysRevLett.112.098101

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We consider the spatial dependence of filamentous protein self-assembly. Through studying the cases where the spreading of aggregated material is dominated either by diffusion or by growth, we derive analytical results for the spatial evolution of filamentous protein aggregation, which we validate against Monte Carlo simulations. Moreover, we compare the predictions of our theory with experimental measurements of two systems for which we identify the propagation as either growth or diffusion controlled. Our results connect the macroscopic observables that characterize the spatial propagation of protein self-assembly with the underlying microscopic processes and provide physical limits on spatial propagation and prionlike behavior associated with protein aggregation.

引用

页数：5

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