Poor responses to tyrosine kinase inhibitors in a child with precursor B-cell acute lymphoblastic leukemia with SNX2-ABL1 chimeric transcript

被引：22

作者：

Masuzawa, Aki ^{[1
]}

Kiyotani, Chikako ^{[1
]}

Osumi, Tomoo ^{[1
]}

Shioda, Yoko ^{[1
]}

Iijima, Kazutoshi ^{[2
,3
]}

Tomita, Osamu ^{[2
]}

Nakabayashi, Kazuhiko ^{[4
]}

Oboki, Keisuke ^{[5
]}

Yasuda, Kazuki ^{[6
]}

Sakamoto, Hiromi ^{[7
]}

Ichikawa, Hitoshi ^{[7
]}

Hata, Kenichiro ^{[4
]}

Yoshida, Teruhiko ^{[7
]}

Matsumoto, Kenji ^{[5
]}

Kiyokawa, Nobutaka ^{[2
]}

Mori, Tetsuya ^{[1
]}

机构：

[1] Natl Ctr Child Hlth & Dev, Div Pediat Oncol, Setagaya Ku, Tokyo, Japan

[2] Natl Res Inst Child Hlth & Dev, Dept Pediat Hematol & Oncol Res, Setagaya Ku, Tokyo 1578535, Japan

[3] Tokyo Univ Sci, Fac Engn, Dept Ind Chem, Shinjuku Ku, Tokyo 162, Japan

[4] Natl Res Inst Child Hlth & Dev, Dept Maternal Fetal Biol, Setagaya Ku, Tokyo 1578535, Japan

[5] Natl Res Inst Child Hlth & Dev, Dept Allergy & Immunol, Setagaya Ku, Tokyo 1578535, Japan

[6] Natl Ctr Global Hlth & Med, Dept Metab Disorder, Diabet Res Ctr, Shinjuku Ku, Tokyo, Japan

[7] Natl Canc Ctr, Res Inst, Div Genet, Chuo Ku, Tokyo 104, Japan

来源：

EUROPEAN JOURNAL OF HAEMATOLOGY | 2014年 / 92卷 / 03期

关键词：

SNX2-ABL1; precursor B-cell acute lymphoblastic leukemia; tyrosine kinase inhibitors; imatinib; dasatinib; FUSION; ABL1; IDENTIFICATION; GENE;

D O I：

10.1111/ejh.12234

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In addition to BCR, various rare fusion partners for the ABL1 gene have been reported in leukemia. We have identified the fusion gene SNX2-ABL1 in a pediatric case of acute lymphoblastic leukemia (ALL), which has only once previously been reported in an adult patient. Cytogenetic analysis detected this fusion gene arising from a t(5;9)(q22;q34) translocation. ALL cells carrying a SNX2-ABL1 fusion exhibited a BCR-ABL1+ ALL-like gene expression profile. The patient poorly responded to dasatinib but partially responded to imatinib. Treatment using tyrosine kinase inhibitors requires further investigation to optimize the genotype-based treatment stratification for patients with SNX2-ABL1 fusion.

引用

页码：263 / 267

页数：5

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