Influence of metal ions on the 68Ga-labeling of DOTATATE

被引：27

作者：

Oehlke, Elisabeth ^{[1
]}

Le, Van So ^{[1
,2
]}

Lengkeek, Nigel ^{[1
]}

Pellegrini, Paul ^{[1
]}

Jackson, Tim ^{[1
]}

Greguric, Ivan ^{[1
]}

Weiner, Ron ^{[1
]}

机构：

[1] Australian Nucl Sci & Technol Org, Div Life Sci, Lucas Heights, NSW, Australia

[2] Med Isotope Tech MEDISOTEC, Gymea, NSW 2227, Australia

来源：

APPLIED RADIATION AND ISOTOPES | 2013年 / 82卷

关键词：

Ga-68; radiolabeling; Metal contaminants; Reaction conditions; Stability; DOTATATE; STABILITY; COMPLEXES; KINETICS; ACID;

D O I：

10.1016/j.apradiso.2013.08.010

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The influence of metal cations (Fe3+, Fe2+, In3+, Cu2+, Ca2+, Al3+, Co2+, Lu3+, Ni2+, Pb2+, Ti4+, Y3+, Yb3+, Zn2+, and Zr4+) on the radiolabeling yield of [Ga-68(DOTATATE)] was evaluated. Our most important observation was that, within our experimental limit, the metal ion/ligand ratio plays a critical role on the influence of most metal ions. More in-depth studies, with Cu2+ and Fe3+, revealed that reaction temperature and concentration changes have little effect, but speciation changes with pH are crucial. Furthermore, we found that [Ga-68(DOTATATE)] is stable in the presence of high concentrations of Fe3+, Zn2+ and Pb2+, but transmetalates with Cu2+ at 95 degrees C. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.

引用

页码：232 / 238

页数：7

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