Pohlianins A, B and C, cyclic peptides from the latex of Jatropha pohliana ssp molissima

被引：48

作者：

Auvin-Guette, C

Baraguey, C

Blond, A

Xavier, HS

Pousset, JL

Bodo, B

机构：

[1] Museum Natl Hist Nat, Lab Chim Subst Nat, URA 401 CNRS, IFR 63 CNRS, F-75005 Paris, France

[2] Univ Fed Pernambuco, Dept Farm, Lab Farmacognosia, BR-50740 Recife, PE, Brazil

来源：

TETRAHEDRON | 1999年 / 55卷 / 38期

关键词：

cyclic peptides; Jatropha; nmr; molecular modeling; beta-bulge;

D O I：

10.1016/S0040-4020(99)00660-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

From the EtOAc extract of the latex of Jatropha pohliana (Euphorbiaceae), two cyclic heptapeptides, pohlianins A (1) and B (2) and one cyclic octapeptide, pohlianin C (3) were isolated by a multi-step chromatography procedure, including HPLC. Their structure were elucidated by chemical degradation, mass spectrometry, homonuclear and heteronuclear NMR experiments. Conformational analysis of these peptides was made by using NMR experiments and distance geometry calculations. Their antimalarial activities were examined. (C) 1999 Elsevier Science Ltd. All rights reserved.

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收藏

页码：11495 / 11510

页数：16

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