High-Relaxivity Gd(III)-Hemicryptophane Complex

被引：12

作者：

Godart, Estelle ^{[1
]}

Long, Augustin ^{[1
]}

Rosas, Roselyne ^{[1
]}

Lemercier, Gilles ^{[2
]}

Jean, Marion ^{[1
]}

Leclerc, Sebastien ^{[3
]}

Bouguet-Bonnet, Sabine ^{[4
]}

Godfrin, Celia ^{[4
]}

Chapellet, Laure-Lise ^{[5
]}

Dutasta, Jean-Pierre ^{[5
]}

Martinez, Alexandre ^{[1
]}

机构：

[1] Aix Marseille Univ, CNRS, Cent Marseille, iSm2, F-ISM2 Marseille, France

[2] Univ Reims, Inst Chim Mol Reims, CNRS, UMR 7312, BP 1039, F-51687 Reims 2, France

[3] Univ Lorraine, CNRS, LEMTA, F-54000 Nancy, France

[4] Univ Lorraine, CNRS, CRM2, F-54000 Nancy, France

[5] UCBL, Lab Chim, Ecole Normale Super Lyon, CNRS, 46 Allee Italie, F-69364 Lyon, France

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 07期

关键词：

MRI CONTRAST AGENTS; SILICA NANOPARTICLES; GADOLINIUM COMPLEX; HEMICRYPTOPHANE; RECOGNITION; CRYPTOPHANE; CONFINEMENT; BIOSENSOR; SENSITIVITY; STABILITY;

D O I：

10.1021/acs.orglett.9b00081

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The polytopic hemicryptophane cage HC1 combining a cyclotriveratrylene (CTV) unit and a tris(2-aminoethyl)amine (tren) moiety connected by three 2-hydroxyisophthalamide linkers was synthesized in 12 steps. The resulting highly functionalized covalent host is soluble in aqueous medium and has been used to complex Gd(III) ion. The Gd(III)@HC1 complex presents promising relaxivity properties when compared to the clinically used Dotarem MRI agent.

引用

页码：1999 / 2003

页数：5

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