High-Relaxivity Gd(III)-Hemicryptophane Complex

被引：12
|
作者：
Godart, Estelle [1 ]
Long, Augustin [1 ]
Rosas, Roselyne [1 ]
Lemercier, Gilles [2 ]
Jean, Marion [1 ]
Leclerc, Sebastien [3 ]
Bouguet-Bonnet, Sabine [4 ]
Godfrin, Celia [4 ]
Chapellet, Laure-Lise [5 ]
Dutasta, Jean-Pierre [5 ]
Martinez, Alexandre [1 ]
机构：
[1] Aix Marseille Univ, CNRS, Cent Marseille, iSm2, F-ISM2 Marseille, France
[2] Univ Reims, Inst Chim Mol Reims, CNRS, UMR 7312, BP 1039, F-51687 Reims 2, France
[3] Univ Lorraine, CNRS, LEMTA, F-54000 Nancy, France
[4] Univ Lorraine, CNRS, CRM2, F-54000 Nancy, France
[5] UCBL, Lab Chim, Ecole Normale Super Lyon, CNRS, 46 Allee Italie, F-69364 Lyon, France
来源：
ORGANIC LETTERS | 2019年 / 21卷 / 07期
关键词：
MRI CONTRAST AGENTS; SILICA NANOPARTICLES; GADOLINIUM COMPLEX; HEMICRYPTOPHANE; RECOGNITION; CRYPTOPHANE; CONFINEMENT; BIOSENSOR; SENSITIVITY; STABILITY;
D O I：
10.1021/acs.orglett.9b00081
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The polytopic hemicryptophane cage HC1 combining a cyclotriveratrylene (CTV) unit and a tris(2-aminoethyl)amine (tren) moiety connected by three 2-hydroxyisophthalamide linkers was synthesized in 12 steps. The resulting highly functionalized covalent host is soluble in aqueous medium and has been used to complex Gd(III) ion. The Gd(III)@HC1 complex presents promising relaxivity properties when compared to the clinically used Dotarem MRI agent.
引用
收藏
页码：1999 / 2003
页数：5
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