Transcriptional control of lymphoid development: Lessons from gene targeting

被引：91

作者：

Clevers, HC ^{[1
]}

Grosschedl, R ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,HOWARD HUGHES MED INST,DEPT MICROBIOL & IMMUNOL,SAN FRANCISCO,CA 94143

来源：

IMMUNOLOGY TODAY | 1996年 / 17卷 / 07期

关键词：

D O I：

10.1016/0167-5699(96)10019-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cis-acting control regions have been defined for many hematopoietic genes and used to identify DNA-binding factors. The orderly expression of these factors is hypothesized to control entry into and progression along the various differentiation pathways. Gene-knockout technology is now unveiling the essential functions of these candidate differentiation control factors. Here, Hans Clevers and Rudolf Grosschedl discuss the results and implications of a number of such gene-disruption experiments.

引用

页码：336 / 343

页数：8

共 59 条

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