Decreased plasma nesfatin-1 levels in patients with acute myocardial infarction

被引：51

作者：

Dai, Hongyan ^{[1
]}

Li, Xiaolu ^{[2
]}

He, Tao ^{[1
]}

Wang, Yanping ^{[1
]}

Wang, Zhengzhong ^{[1
]}

Wang, Shoudong ^{[1
]}

Xing, Mingqing ^{[3
]}

Sun, Wenjuan ^{[1
]}

Ding, Huamin ^{[1
]}

机构：

[1] Qingdao Municipal Hosp, Dept Cardiol, Qingdao, Peoples R China

[2] Shandong Univ, Qianfoshan Hosp, Dept Emergency, Jinan 250100, Peoples R China

[3] Qingdao Municipal Hosp, Dept Clin Lab, Qingdao, Peoples R China

来源：

PEPTIDES | 2013年 / 46卷

基金：

中国国家自然科学基金;

关键词：

Nesfatin-1; Acute myocardial infarction; Angina pectoris; Angiography; ADIPOSE-TISSUE; NEURONS; OBESITY; LEPTIN;

D O I：

10.1016/j.peptides.2013.06.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nesfatin-1 is a novel anorexigenic hormone which has close relationship with diabetes, obese, anorexia nervosa, psychiatric disorders and neurogenic diseases. The aim of our study was to evaluate levels of plasma nesfatin-1 among patients presenting with coronary artery disease and the correlation between nesfatin-1 levels and other clinical parameters. Fasting plasma levels of nesfatin-1 were tested in 48 acute myocardial infarction (AMI) patients, 74 stable angina pectoris (SAP) patients and 34 control subjects. All of them were examined by coronary angiography. The severity of coronary atherosclerosis was assessed using the Gensini score. Plasma nesfatin-1 levels were significantly lower in AMI group than SAP group or control group (0.91 +/- 0.08 ng/mL vs. 0.98 +/- 0.19 ng/mL and 1.09 +/- 0.39 ng/mL, respectively, P < 0.05). In AMI patients, plasma nesfatin-1 levels were negatively correlated with high-sensitivity C-reactive protein, neutrophil% or Gensini scores. Such information implies that lower nesfatin-1 concentration may play a very important role in the development of AMI. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：167 / 171

页数：5

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