tRNA-derived small RNAs: New players in genome protection against retrotransposons

被引：39

作者：

Martinez, German ^{[1
,2
]}

机构：

[1] Swedish Univ Agr Sci, Dept Plant Biol, S-75007 Uppsala, Sweden

[2] Linnean Ctr Plant Biol, S-75007 Uppsala, Sweden

来源：

RNA BIOLOGY | 2018年 / 15卷 / 02期

基金：

瑞典研究理事会;

关键词：

RNAi; RNA silencing; tRNAs; tRFs; tRNA halves; epigenetics; transposable elements; retrotransposons; LTR retrotransposons; TRANSPOSABLE ELEMENTS; MESSENGER-RNAS; FRAGMENTS; STRESS; TRANSLATION; PLANT; METHYLATION; INHIBIT; PIRNAS; IDENTIFICATION;

D O I：

10.1080/15476286.2017.1403000

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previously believed to be mere random degradation products, tRNA-derived small RNAs have been lately connected to a series of functions that include, surprisingly, genome protection against retrotransposons. tRNAs have been known for a long time to be involved in the replication cycle of retroviruses, pararetroviruses and retrotransposons as primers of their reverse transcription. tRNA-derived small RNAs, as functional small RNAs or as mere tRNA degradation products, have emerged as important players in the regulation of genic transcription. Nevertheless, the involvement of functional sRNAs derived from tRNA transcripts in transposon posttranscriptional control is a regulatory layer that remained elusive until now. Here I review the recent discoveries in the field that connect tRNA-derived small RNAs and retrotransposon control.

引用

页码：170 / 175

页数：6

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