The ageing haematopoietic stem cell compartment

被引：418

作者：

Geiger, Hartmut ^{[1
,2
]}

de Haan, Gerald ^{[3
]}

Florian, M. Carolina ^{[1
]}

机构：

[1] Univ Ulm, Dept Dermatol & Allerg Dis, D-89091 Ulm, Germany

[2] Univ Cincinnati, Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Div Expt Hematol & Canc Biol, Cincinnati, OH 45229 USA

[3] Univ Groningen, Univ Med Ctr Groningen, European Res Inst Biol Ageing, Dept Biol Ageing,Ageing Biol & Stem Cells Grp, NL-9713 AV Groningen, Netherlands

来源：

NATURE REVIEWS IMMUNOLOGY | 2013年 / 13卷 / 05期

基金：

美国国家卫生研究院;

关键词：

MITOCHONDRIAL-DNA MUTATIONS; SELF-RENEWAL CAPACITY; AGE-RELATED DEFECTS; EXTENDS LIFE-SPAN; BONE-MARROW; PROGENITOR CELLS; TELOMERE LENGTH; B-LYMPHOPOIESIS; OLD-AGE; DAMAGE;

D O I：

10.1038/nri3433

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Stem cell ageing underlies the ageing of tissues, especially those with a high cellular turnover. There is growing evidence that the ageing of the immune system is initiated at the very top of the haematopoietic hierarchy and that the ageing of haematopoietic stem cells (HSCs) directly contributes to changes in the immune system, referred to as immunosenescence. In this Review, we summarize the phenotypes of ageing HSCs and discuss how the cell-intrinsic and cell-extrinsic mechanisms of HSC ageing might promote immunosenescence. Stem cell ageing has long been considered to be irreversible. However, recent findings indicate that several molecular pathways could be targeted to rejuvenate HSCs and thus to reverse some aspects of immunosenescence.

引用

页码：376 / 389

页数：14

共 156 条

[31] Mouse strain-dependent changes in frequency and proliferation of hematopoietic stem cells during aging: Correlation between lifespan and cycling activity [J].