Polygenic Risk Scores That Predict Common Diseases Using Millions of Single Nucleotide Polymorphisms: Is More, Better?

被引:35
作者
Janssens, A. Cecile J. W. [1 ]
Joyner, Michael J. [2 ]
机构
[1] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, 1518 Clifton Rd NE, Atlanta, GA 30322 USA
[2] Mayo Clin, Dept Anesthesiol & Perioperat Med, Rochester, MN USA
关键词
D O I
10.1373/clinchem.2018.296103
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
[No abstract available]
引用
收藏
页码:609 / 611
页数:3
相关论文
共 6 条
[1]   GWAS to the people [J].
不详 .
NATURE MEDICINE, 2018, 24 (10) :1483-1483
[2]   Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults Implications for Primary Prevention [J].
Inouye, Michael ;
Abraham, Gad ;
Nelson, Christopher P. ;
Wood, Angela M. ;
Sweeting, Michael J. ;
Dudbridge, Frank ;
Lai, Florence Y. ;
Kaptoge, Stephen ;
Brozynska, Marta ;
Wang, Tingting ;
Ye, Shu ;
Webb, Thomas R. ;
Rutter, Martin K. ;
Tzoulaki, Ioanna ;
Patel, Riyaz S. ;
Loos, Ruth J. F. ;
Keavney, Bernard ;
Hemingway, Harry ;
Thompson, John ;
Watkins, Hugh ;
Deloukas, Panos ;
Di Angelantonio, Emanuele ;
Butterworth, Adam S. ;
Danesh, John ;
Samani, Nilesh J. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2018, 72 (16) :1883-1893
[3]   Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations [J].
Khera, Amit V. ;
Chaffin, Mark ;
Aragam, Krishna G. ;
Haas, Mary E. ;
Roselli, Carolina ;
Choi, Seung Hoan ;
Natarajan, Pradeep ;
Lander, Eric S. ;
Lubitz, Steven A. ;
Ellinor, Patrick T. ;
Kathiresan, Sekar .
NATURE GENETICS, 2018, 50 (09) :1219-+
[4]  
Khera AV, 2017, PREPRINT, DOI [10.1101/218388v1, DOI 10.1101/218388V1]
[5]   The personal and clinical utility of polygenic risk scores [J].
Torkamani, Ali ;
Wineinger, Nathan E. ;
Topol, Eric J. .
NATURE REVIEWS GENETICS, 2018, 19 (09) :581-590
[6]   Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores [J].
Vilhjalmsson, Bjarni J. ;
Yang, Jian ;
Finucane, Hilary K. ;
Gusev, Alexander ;
Lindstrom, Sara ;
Ripke, Stephan ;
Genovese, Giulio ;
Loh, Po-Ru ;
Bhatia, Gaurav ;
Do, Ron ;
Hayeck, Tristan ;
Won, Hong-Hee ;
Kathiresan, Sekar ;
Pato, Michele ;
Pato, Carlos ;
Tamimi, Rulla ;
Stahl, Eli ;
Zaitlen, Noah ;
Pasaniuc, Bogdan ;
Belbin, Gillian ;
Kenny, Eimear E. ;
Schierup, Mikkel H. ;
De Jager, Philip ;
Patsopouos, Nikolaos A. ;
Mc Carroll, Steve ;
Daly, Mark ;
Purce, Shaun ;
Chasman, Daniel ;
Neale, Benjamin ;
Goddard, Michael ;
Visscher, Peter M. ;
Kraft, Peter ;
Patterson, Nick ;
Price, Alkes L. .
AMERICAN JOURNAL OF HUMAN GENETICS, 2015, 97 (04) :576-592