Transdermal permeation of tetracaine hydrochloride by lecithin microemulsion: In vivo

被引：57

作者：

Changez, M ^{[1
]}

Chander, J

Dinda, AK

机构：

[1] Indian Inst Technol, Ctr Biomed Engn, New Delhi 110016, India

[2] Technol Bhawan, Dept Sci & Technol, New Delhi 110016, India

[3] All India Inst Mat Sci, Dept Pathol, New Delhi 110028, India

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2006年 / 48卷 / 01期

关键词：

tetracaine hydrochloride; lecithin-microemulsion; local anesthesia; transdermal;

D O I：

10.1016/j.colsurfb.2006.01.007

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

In vivo transdermal permeation of tetracaine hydrochloride encapsulated in lecithin water-in-oil and oil-in-water microemulsion was studied. The effect of the composition of the lecithin microemulsion on analgesic response of tetracaine hydrochloride was evaluated on Wistar rats by tail flick method. To find out the toxicity of lecithin/n-propanol/isopropyl myristate/water/tetracaine hydrochloride microemulsion histopathological and irritation response were measured in Swiss mice. Time course studies were also conducted for the biochemical response of microemulsion by measuring catalase, glutathione and lipid peroxidation levels of the treated mice skin. The analgesic response was found to be dependent on the drug concentration and composition of the systems. The histopathological, irritation and biochemical findings reveal that lecithin/n-propanol/isopropyl myristate/water/tetracaine hydrochloride microemulsion is a safe carrier for transdermal drug delivery systems. Confocal laser scanning microscopy observation indicated that sweat gland and hair follicle also provided the path for transdermal permeation of lecithin/n-propanol/isopropyl myristate/water microemulsion. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：58 / 66

页数：9

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