Clinical effect of preoperative high-dose atorvastatin against no-reflow after PCI

被引:14
作者
Liu, Wenbo [1 ]
Zou, Zhipeng [2 ]
Jiang, Haipeng [3 ]
Li, Qiang [4 ]
Guo, Fangming [4 ]
Wang, Zhen [4 ]
Zhu, Hongguang [5 ]
机构
[1] Yantaishan Hosp, Yantai 264001, Shandong, Peoples R China
[2] Yeda Hosp Yantai City, Dept Cardiol, Yantai 264001, Shandong, Peoples R China
[3] Yantaishan Hosp, Dept Minimally Invas Surg, Yantai 264001, Shandong, Peoples R China
[4] Yantaishan Hosp, Dept Cardiol, Yantai 264001, Shandong, Peoples R China
[5] Haigang Hosp Yantai City, Dept Cardiol, 100 Xingfu Rd, Yantai 264001, Shandong, Peoples R China
关键词
acute coronary syndrome; emergency percutaneous coronary intervention; atorvastatin; cardiac remodeling; PERCUTANEOUS CORONARY INTERVENTION; ACUTE MYOCARDIAL-INFARCTION; THERAPY; SIMVASTATIN; EFFICACY; RATS; SIZE;
D O I
10.3892/etm.2016.3910
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The aim of the present study was to evaluate the use of preoperative high-dose atorvastatin to prevent the no-reflow phenomenon after percutaneous coronary intervention (PCI). A total of 138 patients with ST-segment elevation myocardial infarction, admitted from March 2014 to January 2015, were enrolled and randomly divided into 3 groups of 46 individuals each. The groups included a control group in which patients were not treated with atorvastatin before PCI; a conventional-dose atorvastatin treatment group in which patients received a single dose of 20 mg at bedtime one day prior to PCI; and a high-dose atorvastatin treatment group in which patients were treated with 40 mg divided in two doses the day before PCI. The treatment effects were assessed by re-examining the echocardiography, high-sensitivity C-reactive protein and brain natriuretic peptide (BNP) levels after the PCI. The follow-up examinations included determinations of ultrasound imaging indicators and the contact with patients was maintained for a whole year. The CTFC (frame), pro-BNP, CK-MB peak and WMSI levels of the patients in the high-dose treatment group were significantly lower than those in the conventional dose or the control group. Trombolysis in myocardial infarction <= 2 and myocardial blush grade levels were significantly lower than those in the conventional dose group (P=0.01) or those in the control group (P=0.01), although the echocardiographic indicators of the three groups were not significantly different (P<0.05). Nevertheless, it was found that there were significantly fewer adverse cardiovascular events in the high-dose group (P<0.05 in both cases). During the follow-up period, thromboembolism and restenosis were most infrequent in the high-dose atorvastatin group. Based on our findings the oral administration of high-dose atorvastatin before bedtime, one day before the procedure, can effectively prevent no-reflow cases, reduce adverse events and improve the long-term prognosis for acute coronary syndrome patients after PCI.
引用
收藏
页码:97 / 102
页数:6
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