Circulating microRNAs (cmiRNAs) as novel potential biomarkers for hepatocellular carcinoma

被引：86
|
作者：
Qi, J. [1 ]
Wang, J. [2 ]
Katayama, H. [2 ]
Sen, S. [2 ]
Liu, S. M. [1 ]
机构：
[1] Wuhan Univ, Zhongnan Hosp, Ctr Gene Diag, Wuhan 430072, Hubei, Peoples R China
[2] Univ Texas MD Anderson Canc Ctr, Dept Mol Pathol, Houston, TX 77030 USA
来源：
NEOPLASMA | 2013年 / 60卷 / 02期
基金：
中国国家自然科学基金; 美国国家卫生研究院;
关键词：
circulating microRNAs (cmiRNAs); biomarkers; HCC; diagnosis and prognosis; DES-GAMMA-CARBOXYPROTHROMBIN; ALPHA-FETOPROTEIN; CANCER; EXPRESSION; SERUM; DIAGNOSIS; MIR-122; EPIDEMIOLOGY; SIGNATURES; INFECTION;
D O I：
10.4149/neo_2013_018
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Incidence and mortality associated with hepatocellular carcinoma (HCC) is rising throughout the world. Accurate, noninvasive biomarkers for the early detection of HCC are urgently needed to reduce worldwide morbidity and mortality related to HCC. MicroRNAs (miRNAs), 17- to 25-nucleotide noncoding RNAs that are frequently dysregulated in HCC, have shown great promise as tissue-based markers for HCC diagnosis and prognosis. Moreover, they are stably expressed in serum and urine, and these circulating microRNAs (cmiRNAs) are emerging as novel noninvasive biomarkers for the early detection and prognosis of HCC. This article summarizes the latest findings on the role of circulating miRNAs as potential minimally invasive diagnostic and prognostic biomarkers for HCC.
引用
收藏
页码：135 / 142
页数：8
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